DKK1
DKK1是一種分泌性蛋白質，通常以分泌形式存在于細胞外。它包含一個信號肽（用于分泌）和一個成熟的蛋白質部分。DKK1被認為是Wnt信號通路的抑制劑，這是一種重要的細胞信號傳導通路，參與細胞增殖、分化和胚胎發育等過程。此外，DKK1在骨代謝中也扮演著重要角色。它具有抑制骨細胞活性的作用，導致骨吸收和骨形成之間的平衡失調。由于DKK1在多個生理和病理過程中的關鍵作用，研究人員正在探索將其作為潛在治療靶點的可能性。特別是在骨相關疾病和一些腫瘤的治療中，通過調節DKK1的功能，可能提供新的治療策略。
更多相關閱讀：DKK1：經典的Wnt/β-catenin通路拮抗劑，癌癥雙向調控靶點？
熱銷產品
● Recombinant Human Dickkopf-related protein 1(DKK1) (Active) CSB-MP006920HU(A4)
驗證數據
-SDS.jpg)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Activity: Measured by its binding ability in a functional ELISA. Immobilized Human DKK1 at 2 μg/mL can bind Anti-DKK1 recombinant antibody (CSB-RA006920MA1HU), the EC50 is 1.283-2.544 ng/mL.
DKK1 Antibodies
DKK1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA006126 | DKK1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA120268 | DKK1 Antibody | Human,Mouse | ELISA,WB |
| CSB-PA06219A0Rb | DKK1 Antibody | Human | ELISA, IHC, IF |
| CSB-RA576260A0HU | DKK1 Recombinant Monoclonal Antibody | Human | ELISA, WB |
| CSB-RA006920MA1HU | DKK1 Recombinant Monoclonal Antibody | Human | ELISA |
DKK1 Proteins
DKK1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006920HU CSB-BP006920HU CSB-MP006920HU CSB-EP006920HU-B |
Recombinant Human Dickkopf-related protein 1 (DKK1), partial Yeast | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP006920HU | Recombinant Human Dickkopf-related protein 1 (DKK1), partial Escherichia Coli | E.coli |
| CSB-MP006920HU(A4) | Recombinant Human Dickkopf-related protein 1 (DKK1) (Active) | Mammalian cell |
DKK1 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006920MO CSB-EP006920MO CSB-BP006920MO CSB-MP006920MO CSB-EP006920MO-B |
Recombinant Mouse Dickkopf-related protein 1 (Dkk1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DKK1 ELISA Kit
DKK1 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E10104h | Human Dickkopf 1,DKK1 ELISA Kit | serum, plasma, tissue homogenates | 15.6 pg/mL |
DKK1 ELISA Kit for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL006920MO | Mouse Dickkopf-related protein 1(DKK1) ELISA kit | serum, plasma, tissue homogenates | 13.127 pg/mL |
