DAB2
Disabled homolog 2 is a protein in humans that is encoded by DAB2 gene. Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development.
DAB2 Antibodies
DAB2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA006480GA01HU | DAB2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA337435 | DAB2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA574764 | DAB2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
DAB2 Proteins
DAB2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006480HU CSB-EP006480HU CSB-BP006480HU CSB-MP006480HU CSB-EP006480HU-B |
Recombinant Human Disabled homolog 2 (DAB2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DAB2 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006480MO CSB-EP006480MO CSB-BP006480MO CSB-MP006480MO CSB-EP006480MO-B |
Recombinant Mouse Disabled homolog 2 (Dab2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
DAB2 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP006480RA CSB-EP006480RA CSB-BP006480RA CSB-MP006480RA CSB-EP006480RA-B |
Recombinant Rat Disabled homolog 2 (Dab2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
