CYBB
CYBB全稱為細(xì)胞色素b-245重鏈（Cytochrome b-245 heavy chain），又稱NOX2或gp91phox，是NADPH氧化酶復(fù)合物的核心催化亞基。CYBB主要分布于中性粒細(xì)胞、單核細(xì)胞等吞噬細(xì)胞的細(xì)胞膜上，負(fù)責(zé)催化氧分子生成超氧陰離子，構(gòu)成機(jī)體抵抗病原微生物的關(guān)鍵防線。當(dāng)免疫細(xì)胞識別入侵病原體時(shí)，CYBB蛋白會(huì)與多個(gè)調(diào)控亞基組裝形成活性酶復(fù)合體，通過"呼吸爆發(fā)"產(chǎn)生大量活性氧直接殺傷細(xì)菌，這一過程被稱為氧化殺菌作用。CYBB基因突變會(huì)導(dǎo)致慢性肉芽腫病（CGD），患者因無法有效清除病原體而反復(fù)發(fā)生嚴(yán)重感染，并伴隨肉芽腫形成和炎癥過度反應(yīng)。針對該疾病的治療除了抗生素預(yù)防和干擾素-γ輔助治療外，干細(xì)胞基因治療已進(jìn)入臨床試驗(yàn)階段，通過回輸攜帶正常CYBB基因的造血干細(xì)胞實(shí)現(xiàn)功能修復(fù)。基于NOX2調(diào)控機(jī)制的抗氧化劑和抗炎藥物研究也為相關(guān)免疫缺陷及炎癥性疾病提供了新思路。
熱銷產(chǎn)品
Recombinant Human Cytochrome b-245 heavy chain (CYBB), partial (CSB-EP006325HU1)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CYBB Recombinant Monoclonal Antibody (CSB-RA006325MA1HU)
驗(yàn)證數(shù)據(jù)
Immunofluorescence staining of hela cell with CSB-RA006325MA1HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Mouse IgG(H+L).
CYBB Antibodies
CYBB for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA006325KA01HU | CYBB Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA006325LA01HU | CYBB Antibody | Human | ELISA, IHC, IF |
| CSB-PA006325LC01HU | CYBB Antibody, FITC conjugated | Human | |
| CSB-PA002737 | CYBB Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA005619 | CYBB Antibody | Human | WB, ELISA |
| CSB-PA176464 | CYBB Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA140004 | CYBB Antibody | Human,Mouse | ELISA,IHC |
| CSB-RA006325MA1HU | CYBB Recombinant Monoclonal Antibody | Human | ELISA, IF |
CYBB Proteins
CYBB Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP006325PI1 CSB-EP006325PI1 CSB-BP006325PI1 CSB-MP006325PI1 CSB-EP006325PI1-B |
Recombinant Pig Cytochrome b-245 heavy chain (CYBB), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006325PI | Recombinant Pig Cytochrome b-245 heavy chain (CYBB) | in vitro E.coli expression system |
CYBB Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP006325HU CSB-EP006325HU CSB-BP006325HU CSB-MP006325HU CSB-EP006325HU-B |
Recombinant Human Cytochrome b-245 heavy chain (CYBB), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP006325HU1 | Recombinant Human Cytochrome b-245 heavy chain (CYBB), partial | E.coli |
| CSB-CF006325HU | Recombinant Human Cytochrome b-245 heavy chain (CYBB) | in vitro E.coli expression system |
| CSB-EP006325HU1a2 | Recombinant Human Cytochrome b-245 heavy chain (CYBB), partial | E.coli |
| CSB-YP006325HU1 | Recombinant?Human?Cytochrome?b-245?heavy?chain (CYBB), partial | Yeast |
CYBB Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP006325BO1 CSB-EP006325BO1 CSB-BP006325BO1 CSB-MP006325BO1 CSB-EP006325BO1-B |
Recombinant Bovine Cytochrome b-245 heavy chain (CYBB), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006325BO | Recombinant Bovine Cytochrome b-245 heavy chain (CYBB) | in vitro E.coli expression system |
CYBB Proteins for Escherichia coli (strain K12)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP006306ENV1 CSB-EP006306ENV1 CSB-BP006306ENV1 CSB-MP006306ENV1 CSB-EP006306ENV1-B |
Recombinant Escherichia coli Cytochrome b561 (cybB), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006306ENV | Recombinant Escherichia coli Cytochrome b561 (cybB) | in vitro E.coli expression system |
CYBB Proteins for Shigella flexneri
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP006306SZB1 CSB-EP006306SZB1 CSB-BP006306SZB1 CSB-MP006306SZB1 CSB-EP006306SZB1-B |
Recombinant Cytochrome b561 (cybB), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006306SZB | Recombinant Cytochrome b561 (cybB) | in vitro E.coli expression system |
CYBB Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP733771MO1 CSB-EP733771MO1 CSB-BP733771MO1 CSB-MP733771MO1 CSB-EP733771MO1-B |
Recombinant Mouse Cytochrome b-245 heavy chain (Cybb), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF733771MO | Recombinant Mouse Cytochrome b-245 heavy chain (Cybb) | in vitro E.coli expression system |
CYBB Proteins for Bison bison (American bison) (Bos bison)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP836099BTE1 CSB-EP836099BTE1 CSB-BP836099BTE1 CSB-MP836099BTE1 CSB-EP836099BTE1-B |
Recombinant Bison bison Cytochrome b-245 heavy chain (CYBB), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF836099BTE | Recombinant Bison bison Cytochrome b-245 heavy chain (CYBB) | in vitro E.coli expression system |
CYBB Proteins for Yersinia pestis
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP893085YAS1 CSB-EP893085YAS1 CSB-BP893085YAS1 CSB-MP893085YAS1 CSB-EP893085YAS1-B |
Recombinant Probable cytochrome b561 (cybB), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF893085YAS | Recombinant Probable cytochrome b561 (cybB) | in vitro E.coli expression system |
