CYB5R3

CYB5R3，全稱為NADH-cytochrome b5 reductase 3，常見別名有DIA1和B5R。該蛋白參與脂肪酸的延伸和去飽和、膽固醇的生物合成以及藥物代謝。在紅細(xì)胞中，CYB5R3涉及高鐵血紅蛋白的還原。突變的CYB5R3基因可導(dǎo)致高鐵血紅蛋白血癥，表現(xiàn)為血液中高鐵血紅蛋白濃度過高，從而影響氧輸送，引發(fā)紫紺和缺氧癥狀。膜結(jié)合形式的CYB5R3則參與脂肪酸的延伸和去飽和、膽固醇的生物合成以及藥物代謝。研究表明，在過表達(dá)CYB5R3的癌細(xì)胞中，缺氧誘導(dǎo)因子-1(HIF-1)的表達(dá)顯著降低，從而抑制了癌細(xì)胞生長、體內(nèi)腫瘤生長和轉(zhuǎn)移。基于這一發(fā)現(xiàn)，CYB5R3被研究作為預(yù)防和治療癌癥的藥物組合物的活性成分。目前，已有相關(guān)專利申請涉及將CYB5R3基因或蛋白用于開發(fā)抗癌藥物。

熱銷產(chǎn)品

CYB5R3 Antibody (CSB-PA02655A0Rb)

驗(yàn)證數(shù)據(jù)

Western blot
All lanes: CYB5R3 antibody at 2µg/ml + 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 35, 32, 39 kDa
Observed band size: 32 kDa

Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA02655A0Rb at dilution of 1:100

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA02655A0Rb at dilution of 1:100

Immunofluorescent analysis of Hela cells using CSB-PA02655A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Human NADH-cytochrome b5 reductase 3(CYB5R3) ELISA kit (CSB-EL006320HU)

驗(yàn)證數(shù)據(jù)

貨號：CSB-EL006320HU

規(guī)格：96T/48T

靈敏度：6.25pg/ml

檢測范圍：25 pg/ml-1600 pg/ml

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

CYB5R3 Antibody

CYB5R3 Protein

CYB5R3 ELISA Kit

CYB5R3 Antibodies

CYB5R3 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA02655A0Rb	CYB5R3 Antibody	Human	ELISA, WB, IHC, IF
CSB-PA006320GA01HU	CYB5R3 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA178677	CYB5R3 Antibody	Human	ELISA,WB,IHC
CSB-PA001856	CYB5R3 Antibody	Human	WB, IHC, ELISA

CYB5R3 Proteins

CYB5R3 Proteins for Sus scrofa (Pig)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP006320PI CSB-EP006320PI CSB-BP006320PI CSB-MP006320PI CSB-EP006320PI-B	Recombinant Pig NADH-cytochrome b5 reductase 3 (CYB5R3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CYB5R3 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP006320RA CSB-EP006320RA CSB-BP006320RA CSB-MP006320RA CSB-EP006320RA-B	Recombinant Rat NADH-cytochrome b5 reductase 3 (Cyb5r3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CYB5R3 Proteins for Bos taurus (Bovine)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP006320BO CSB-EP006320BO CSB-BP006320BO CSB-MP006320BO CSB-EP006320BO-B	Recombinant Bovine NADH-cytochrome b5 reductase 3 (CYB5R3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CYB5R3 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP006320HU CSB-EP006320HU CSB-BP006320HU CSB-MP006320HU CSB-EP006320HU-B	Recombinant Human NADH-cytochrome b5 reductase 3 (CYB5R3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CYB5R3 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP607302DO CSB-EP607302DO CSB-BP607302DO CSB-MP607302DO CSB-EP607302DO-B	Recombinant Dog NADH-cytochrome b5 reductase 3 (CYB5R3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CYB5R3 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP720221MOV CSB-EP720221MOV CSB-BP720221MOV CSB-MP720221MOV CSB-EP720221MOV-B	Recombinant Macaca fascicularis NADH-cytochrome b5 reductase 3 (CYB5R3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CYB5R3 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP887597MO CSB-BP887597MO CSB-MP887597MO CSB-EP887597MO-B	Recombinant Mouse NADH-cytochrome b5 reductase 3 (Cyb5r3)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli