CXCR5
CXCR5，即C-X-C基序趨化因子受體5，別名CD185。它是一種G蛋白偶聯(lián)受體，屬于趨化因子受體家族成員，主要在B細(xì)胞、濾泡輔助性T細(xì)胞（Tfh）、一些T細(xì)胞亞群和一些樹(shù)突狀細(xì)胞上表達(dá)。CXCR5的作用機(jī)制是通過(guò)與特定的配體CXCL13結(jié)合，這種結(jié)合激活了受體，進(jìn)而觸發(fā)細(xì)胞內(nèi)信號(hào)傳導(dǎo)，如通過(guò)Gαi蛋白激活PI3K、AKT和ERK/MAPK等信號(hào)通路，導(dǎo)致細(xì)胞的遷移、增殖和分化。CXCR5在生物學(xué)上的意義主要體現(xiàn)在其對(duì)B細(xì)胞和Tfh細(xì)胞的遷移和定位的調(diào)控作用。在次級(jí)淋巴器官如淋巴結(jié)和脾臟中，CXCR5與其配體CXCL13的相互作用對(duì)于形成B細(xì)胞濾泡和Tfh細(xì)胞區(qū)至關(guān)重要，這對(duì)于適應(yīng)性免疫反應(yīng)的發(fā)生和維持至關(guān)重要。此外，CXCR5也在某些自身免疫性疾病、炎癥性疾病和腫瘤中發(fā)揮作用，其表達(dá)水平的變化可能與疾病的進(jìn)展相關(guān)。因此，CXCR5是免疫學(xué)研究和相關(guān)疾病治療中的一個(gè)潛在靶點(diǎn)。
熱銷產(chǎn)品
Recombinant Human C-X-C chemokine receptor type 5 (CXCR5), partial (CSB-YP006255HU1a4)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CXCR5 Antibody (CSB-PA006255LA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA006255LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human lymph node tissue using CSB-PA006255LA01HU at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using CSB-PA006255LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
CXCR5 Antibodies
CXCR5 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA006273 | CXCR5 Antibody | Human | WB, ELISA |
| CSB-PA158258 | CXCR5 Antibody | Human | ELISA,IHC |
| CSB-PA006255LA01HU | CXCR5 Antibody | Human | ELISA, IHC, IF |
| CSB-PA006255LD01HU | CXCR5 Antibody, Biotin conjugated | Human | ELISA |
CXCR5 Proteins
CXCR5 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP006255RA1 CSB-EP006255RA1 CSB-BP006255RA1 CSB-MP006255RA1 CSB-EP006255RA1-B |
Recombinant Rat C-X-C chemokine receptor type 5 (Cxcr5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006255RA | Recombinant Rat C-X-C chemokine receptor type 5 (Cxcr5) | in vitro E.coli expression system |
CXCR5 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-BP006255HU1 CSB-MP006255HU1 CSB-EP006255HU1-B |
Recombinant Human C-X-C chemokine receptor type 5 (CXCR5), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF006255HU | Recombinant Human C-X-C chemokine receptor type 5 (CXCR5) | in vitro E.coli expression system |
| CSB-YP006255HU1 | Recombinant Human C-X-C chemokine receptor type 5 (CXCR5), partial | Yeast |
| CSB-YP006255HU1b0 | Recombinant Human C-X-C chemokine receptor type 5 (CXCR5), partial | Yeast |
| CSB-YP006255HU1a4 | Recombinant Human C-X-C chemokine receptor type 5 (CXCR5), partial | Yeast |
| CSB-EP006255HU1 | Recombinant Human C-X-C chemokine receptor type 5(CXCR5), partial | E.coli |
