CTSB

組織蛋白酶B（Cathepsin B）是一種溶酶體半胱氨酸蛋白酶，常被簡(jiǎn)稱為CathB或CTSB。這種酶在正常生理狀態(tài)下負(fù)責(zé)降解受損蛋白質(zhì)，維持細(xì)胞穩(wěn)態(tài)，但在病理?xiàng)l件下可能促進(jìn)腫瘤侵襲與炎癥反應(yīng)。研究發(fā)現(xiàn)，其過(guò)度激活會(huì)破壞細(xì)胞外基質(zhì)，加速癌細(xì)胞穿透血管壁形成轉(zhuǎn)移灶，在乳腺癌、膠質(zhì)瘤等多種惡性腫瘤中呈現(xiàn)高表達(dá)特征。此外，該蛋白酶還參與阿爾茨海默病的β淀粉樣蛋白沉積過(guò)程，并能激活炎癥小體加重類風(fēng)濕性關(guān)節(jié)炎。

近年來(lái)針對(duì)CTSB的藥物開發(fā)聚焦于特異性抑制劑，例如CA-074系列化合物已顯示出阻斷腫瘤轉(zhuǎn)移的潛力。部分研究嘗試將CTSB抑制劑與免疫檢查點(diǎn)療法聯(lián)用，通過(guò)調(diào)控腫瘤微環(huán)境增強(qiáng)抗PD-1治療效果。在神經(jīng)退行性疾病領(lǐng)域，小分子抑制劑Esteya表現(xiàn)出抑制tau蛋白異常磷酸化的作用，目前處于臨床前研究階段。值得注意的是，新冠病毒感染研究中發(fā)現(xiàn)CTSB可能參與病毒刺突蛋白的切割激活，這為抗病毒藥物研發(fā)提供了新思路。

熱銷產(chǎn)品

Recombinant Human Cathepsin B (CTSB), partial (CSB-EP006185HU1e1)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CTSB Antibody (CSB-PA06974A0Rb)

驗(yàn)證數(shù)據(jù)

Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA06974A0Rb at dilution of 1:100

Western Blot
Positive WB detected in: Mouse heart tissue, Mouse liver tissue
All lanes: CTSB antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 38 kDa
Observed band size: 38 kDa

Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA06974A0Rb at dilution of 1:100

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA06974A0Rb at dilution of 1:100

Immunofluorescent analysis of A375 cells using CSB-PA06974A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Human cathepsin B (CTSB) ELISA kit (CSB-E13450h)

驗(yàn)證數(shù)據(jù)

貨號(hào)：CSB-E13450h

規(guī)格：96T/48T

靈敏度：0.078 ng/mL

檢測(cè)范圍：0.312 ng/mL-20 ng/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

CTSB Antibody

CTSB Protein

CTSB ELISA Kit

CTSB Antibodies

CTSB for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA06974A0Rb	CTSB Antibody	Human, Mouse	ELISA, WB, IHC, IF
CSB-PA06974B0Rb	CTSB Antibody, HRP conjugated	Human	ELISA
CSB-PA06974C0Rb	CTSB Antibody, FITC conjugated	Human
CSB-PA06974D0Rb	CTSB Antibody, Biotin conjugated	Human	ELISA
CSB-PA006185GA01HU	CTSB Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA001296	CTSB Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA047604	CTSB Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA825136	CTSB Antibody	Human,Mouse,Rat	ELISA,IHC

CTSB Proteins

CTSB Proteins for Ovis aries (Sheep)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP006185SH CSB-EP006185SH CSB-BP006185SH CSB-MP006185SH CSB-EP006185SH-B	Recombinant Sheep Cathepsin B (CTSB)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTSB Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP006185MO CSB-EP006185MO CSB-BP006185MO CSB-MP006185MO CSB-EP006185MO-B	Recombinant Mouse Cathepsin B (Ctsb)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTSB Proteins for Gallus gallus (Chicken)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP006185CH CSB-EP006185CH CSB-BP006185CH CSB-MP006185CH CSB-EP006185CH-B	Recombinant Chicken Cathepsin B (CTSB)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTSB Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP006185RA CSB-EP006185RA CSB-BP006185RA CSB-MP006185RA CSB-EP006185RA-B	Recombinant Rat Cathepsin B (Ctsb)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTSB Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-EP006185HU CSB-BP006185HU CSB-MP006185HU CSB-EP006185HU-B	Recombinant Human Cathepsin B (CTSB)	E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP006185HU1	Recombinant Human Cathepsin B (CTSB), partial	E.coli
CSB-AP005381HU	Recombinant Human Cathepsin B (CTSB), partial (Active)	Mammalian cell
CSB-EP006185HU1e1	Recombinant Human Cathepsin B (CTSB), partial	E.coli
CSB-YP006185HU	Recombinant Human Cathepsin B (CTSB)	Yeast
CSB-MP006185HU3(M)	Recombinant Human Cathepsin B (CTSB)(L26V)	Mammalian cell

CTSB Proteins for Bos taurus (Bovine)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP006185BO CSB-EP006185BO CSB-BP006185BO CSB-MP006185BO CSB-EP006185BO-B	Recombinant Bovine Cathepsin B (CTSB)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTSB Proteins for Sus scrofa (Pig)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP006185PI CSB-EP006185PI CSB-BP006185PI CSB-MP006185PI CSB-EP006185PI-B	Recombinant Pig Cathepsin B (CTSB)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTSB Proteins for Coturnix coturnix japonica (Japanese quail) (Coturnix japonica)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP006185DXJ CSB-EP006185DXJ CSB-BP006185DXJ CSB-MP006185DXJ CSB-EP006185DXJ-B	Recombinant Coturnix coturnix japonica Cathepsin B (CTSB)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTSB Proteins for Dictyostelium discoideum (Slime mold)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP006185DKK CSB-EP006185DKK CSB-BP006185DKK CSB-MP006185DKK CSB-EP006185DKK-B	Recombinant Dictyostelium discoideum Cathepsin B (ctsB)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTSB Proteins for Pongo abelii (Sumatran orangutan)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP006185PYX CSB-EP006185PYX CSB-BP006185PYX CSB-MP006185PYX CSB-EP006185PYX-B	Recombinant Pongo abelii Cathepsin B (CTSB)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CTSB Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP006185MOV CSB-EP006185MOV CSB-BP006185MOV CSB-MP006185MOV CSB-EP006185MOV-B	Recombinant Macaca fascicularis Cathepsin B (CTSB)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli