CSF1
CSF1，全稱集落刺激因子1，是一種重要的細(xì)胞因子，常見別名包括M-CSF（巨噬細(xì)胞集落刺激因子）。該蛋白主要參與巨噬細(xì)胞的生成、分化和功能調(diào)控，對單核細(xì)胞和巨噬細(xì)胞的存活、增殖和更新起著關(guān)鍵作用。CSF1通過與CSF1R受體結(jié)合，激活下游信號，影響巨噬細(xì)胞的功能，包括刺激吞噬和趨化活性。此外，CSF1還可能參與胎盤的發(fā)育，并在多種疾病中發(fā)揮作用，如抗基底膜腎炎、高級別腦膠質(zhì)瘤和骨病等。CSF1與系統(tǒng)性硬皮病和間質(zhì)性膀胱炎也有關(guān)聯(lián)。
近年來，針對CSF1/CSF1R靶點(diǎn)的藥物研發(fā)取得顯著進(jìn)展。例如，和譽(yù)醫(yī)藥的匹米替尼已進(jìn)入Ⅲ期臨床階段，顯示出對腱鞘巨細(xì)胞瘤的顯著療效，其最佳客觀緩解率高達(dá)85.0%。此外，Ono公司的Vimseltinib作為全球第二款創(chuàng)新CSF1R抑制劑，也已獲FDA批準(zhǔn)上市，用于治療不適合手術(shù)的腱鞘巨細(xì)胞瘤。這些進(jìn)展為巨噬細(xì)胞相關(guān)疾病的治療提供了新的選擇，展現(xiàn)了CSF1蛋白在疾病治療中的巨大潛力。
熱銷產(chǎn)品
Recombinant Human Macrophage colony-stimulating factor 1 (CSF1), partial (Active) (CSB-YP006043HU1)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
The ED50 as determined by the dose-dependent stimulation of the proliferation of THP-1 cells is 0.5913-1.205 ng/mL.
Recombinant Human Macrophage colony-stimulating factor 1 (CSF1), partial (Active) (CSB-MP006043HU1)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
The ED50 as determined by the dose-dependent stimulation of the proliferation of THP-1 cells is 2.880-4.115 ng/mL.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CSF1 protein at 2 μg/ml can bind Anti-CSF1 recombinant antibody (CSB-RA006043MA1HU). The EC50 is 4.291-4.988 ng/mL.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CSF1 protein at 2 μg/ml can bind Human CSF1R protein (CSB-MP006044HU). The EC50 is 37.37-43.34 ng/mL.
CSF1 Antibody (CSB-PA06859A0Rb)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA06859A0Rb at dilution of 1:100
Immunofluorescent analysis of A549 cells using CSB-PA06859A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Human Macrophage Colony-Stimulating Factor,M-CSF ELISA kit (CSB-E04658h)
驗(yàn)證數(shù)據(jù)
貨號：CSB-E04658h
規(guī)格：96T/48T
靈敏度：0.039 ng/ml
檢測范圍：0.156 ng/ml - 10 ng/ml
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
CSF1 Antibodies
CSF1 for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA07777A0Rb | Csf1 Antibody | Mouse | ELISA |
| CSB-PA07779A0Rb | Csf1 Antibody | Mouse | ELISA, IHC |
CSF1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA06859A0Rb | CSF1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA006115 | CSF1 Antibody | Human | WB, ELISA |
CSF1 Proteins
CSF1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-EP006043MO CSB-BP006043MO CSB-EP006043MO-B |
Recombinant Mouse Macrophage colony-stimulating factor 1 (Csf1), partial | E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP006043MO | Recombinant Mouse Macrophage colony-stimulating factor 1 (Csf1), partial | E.coli |
| CSB-AP003461MO | Recombinant Mouse Macrophage colony-stimulating factor 1 protein (Csf1), partial (Active) | E.Coli |
| CSB-CF006043MO(A4) | Recombinant Mouse Macrophage colony-stimulating factor 1 (Csf1) | in vitro E.coli expression system |
| CSB-AP003641MO | Recombinant Mouse Macrophage colony-stimulating factor 1 (Csf1), partial (Active) | Mammalian cell |
CSF1 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP613201SVG CSB-EP613201SVG CSB-BP613201SVG CSB-MP613201SVG CSB-EP613201SVG-B |
Recombinant Saccharomyces cerevisiae Protein CSF1 (CSF1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSF1 Proteins for Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP765584DOT CSB-EP765584DOT CSB-BP765584DOT CSB-MP765584DOT CSB-EP765584DOT-B |
Recombinant Ashbya gossypii Protein CSF1 (CSF1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSF1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP810353RA CSB-BP810353RA CSB-MP810353RA CSB-EP810353RA-B |
Recombinant Rat Macrophage colony-stimulating factor 1 (Csf1), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSF1 Proteins for Homo sapiens (Human)
CSF1 ELISA Kit
CSF1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04658h | Human Macrophage Colony-Stimulating Factor,M-CSF ELISA kit | serum, plasma, tissue homogenates | 0.039 ng/ml |
CSF1 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E04659m | Mouse Macrophage Colony-Stimulating Factor,M-CSF ELISA kit | serum, plasma, tissue homogenates | 1.95 pg/mL |
CSF1 ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E07424r | Rat Macrophage Colony-Stimulating Factor,M-CSF ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 0.039 ng/ml |
