CRTC2
CRTC2,全稱為CREB調節轉錄共激活因子2,是一種與血糖調節密切相關的蛋白。該蛋白在胰島素信號通路中發揮重要作用,能夠結合并激活CREB蛋白,進而促進下游基因的表達。CRTC2蛋白的活性受到多種因素的調控,包括細胞內鈣離子濃度、AMPK信號通路等。在胰島素作用下,CRTC2蛋白的活性增強,從而促進糖異生相關基因的表達,增加血糖水平。CRTC2蛋白與糖尿病的發生發展密切相關,其過度激活會導致胰島素抵抗、脂肪肝和肥胖等代謝性疾病。針對CRTC2蛋白的藥物研發已成為糖尿病治療的重要方向。研究人員發現,阿匹地靈C等天然產物能夠抑制CRTC2蛋白與CREB蛋白的結合,從而降低糖異生相關基因的表達,達到降低血糖的效果。在此基礎上,研究人員進一步設計了靶向CRTC2蛋白的先導化合物A57,該化合物對CRTC2蛋白的抑制作用比阿匹地靈C強30倍,能夠有效降低糖尿病小鼠的血糖和血脂水平。CRTC2蛋白相關藥物的研發為糖尿病治療提供了新的靶點和策略。
熱銷產品
CRTC2 Antibody (CSB-PA706631LA01HU)
驗證數據

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA706631LA01HU at dilution of 1:100

Immunofluorescent analysis of Hela cells using CSB-PA706631LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
CRTC2 Antibodies
CRTC2 for Homo sapiens (Human)
產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
---|---|---|---|
CSB-PA006001GA01HU | CRTC2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
CSB-PA832743 | CRTC2 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA706631LA01HU | CRTC2 Antibody | Human | ELISA, IHC, IF |
CRTC2 Proteins
CRTC2 Proteins for Mus musculus (Mouse)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP663643MO CSB-EP663643MO CSB-BP663643MO CSB-MP663643MO CSB-EP663643MO-B |
Recombinant Mouse CREB-regulated transcription coactivator 2 (Crtc2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CRTC2 Proteins for Rattus norvegicus (Rat)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP667310RA CSB-EP667310RA CSB-BP667310RA CSB-MP667310RA CSB-EP667310RA-B |
Recombinant Rat CREB-regulated transcription coactivator 2 (Crtc2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CRTC2 Proteins for Homo sapiens (Human)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP706631HU CSB-EP706631HU CSB-BP706631HU CSB-MP706631HU CSB-EP706631HU-B |
Recombinant Human CREB-regulated transcription coactivator 2 (CRTC2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |