CRLF2
CDLF2，即細胞因子受體樣因子2，別名CRLF2。它是由人類CRLF2基因編碼的I型細胞因子受體家族成員。CRLF2蛋白是胸腺基質淋巴生成素（TSLP）的受體，與白細胞介素7受體（IL7R）一起，能夠激活STAT3、STAT5和JAK2途徑，這些途徑控制著細胞增殖和造血系統發(fā)育等過程。CRLF2的作用機制涉及與TSLP和IL7R形成功能性復合體，通過激活JAK-STAT信號通路來刺激細胞增殖。CRLF2在正常B淋巴細胞的發(fā)育中起重要作用，但在急性淋巴細胞白血病（ALL）中，CRLF2的過表達或重排與疾病的發(fā)生發(fā)展有關，尤其是在Ph樣ALL（費城染色體樣急性淋巴細胞白血病）中，CRLF2的重排導致細胞表面CRLF2高表達，刺激前B淋巴細胞增殖，與不良預后相關。
熱銷產品
CRLF2 Antibody (CSB-PA005983ESR1HU)
驗證數據
Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA005983ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA005983ESR1HU at dilution of 1:100
CRLF2 Antibodies
CRLF2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA905549 | CRLF2 Antibody | Human | ELISA,IHC |
| CSB-PA976066 | CRLF2 Antibody | Human | ELISA,WB,IHC |
| CSB-PA005983ESR1HU | CRLF2 Antibody | Human | ELISA, IHC |
CRLF2 Proteins
CRLF2 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP005983MO CSB-EP005983MO CSB-BP005983MO CSB-MP005983MO CSB-EP005983MO-B |
Recombinant Mouse Cytokine receptor-like factor 2 (Crlf2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CRLF2 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP005983RA CSB-EP005983RA CSB-BP005983RA CSB-MP005983RA CSB-EP005983RA-B |
Recombinant Rat Cytokine receptor-like factor 2 (Crlf2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CRLF2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP005983HU CSB-EP005983HU CSB-BP005983HU CSB-MP005983HU CSB-EP005983HU-B |
Recombinant Human Cytokine receptor-like factor 2 (CRLF2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
