CLDN4
Claudin 4( CLDN4 )是一種緊密連接蛋白，是Claudin 家族的一員，Claudin 蛋白均由4個跨膜結構域構成，N端和C端均位于細胞內部，細胞膜外有2個長度不等的環，可以和臨近其他同類型的環相接觸構成細胞間的緊密連接． 而且CLDN4的結構高度保守，從線蟲到人類都十分相似．當Claudin蛋白發生變化時將影響細胞間的通透性進一步引起多種疾病的發生．研究報道CLDN4 在卵巢癌、前列腺癌、乳腺癌、胰腺癌、腸道癌等多種腫瘤中表達上調，并且作為一種癌基因介導癌癥的發生。
CUSABIO-哺乳包膜VIPs平臺成功開發CLDN4全長跨膜蛋白（4次跨膜），展示了完整生物活性。
熱銷產品
Recombinant Human Claudin-4(CLDN4)-VLPs (Active) (CSB-MP005506HU)
CSB-MP005506HU is detected by Mouse anti-6*His monoclonal antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN4 at 5 μg/ml can bind Anti-CLDN4 recombinant antibody (CSB-RA005506MA1HU), the EC50 is 29.56-50.75 ng/mL
● CLDN4 Recombinant Monoclonal Antibody CSB-RA005506MA2HU
驗證數據
Overlay Peak curve showing MCF7 cells stained with CSB-RA005506MA2HU (red line) at 1:100. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
CLDN4 Antibodies
CLDN4 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA005506GA01HU | CLDN4 Antibody | Human, Mouse, Rat | ELISA, WB |
| CSB-PA001662 | CLDN4 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA007220 | Phospho-CLDN4 (Y208) Antibody | Human | IHC, ELISA |
| CSB-PA007221 | CLDN4 Antibody | Human | WB, IHC, ELISA |
| CSB-PA086155 | CLDN4 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA275606 | CLDN4 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-RA005506A0HU | CLDN4 Recombinant Monoclonal Antibody | Human | ELISA |
| CSB-RA005506MA1HU | CLDN4 Recombinant Monoclonal Antibody | Human | ELISA |
| CSB-RA005506MA2HU | CLDN4 Recombinant Monoclonal Antibody | Human | ELISA, FC |
CLDN4 Proteins
CLDN4 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP005506HU1 CSB-EP005506HU1 CSB-BP005506HU1 CSB-MP005506HU1 CSB-EP005506HU1-B |
Recombinant Human Claudin-4 (CLDN4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF005506HU | Recombinant Human Claudin-4 (CLDN4) | in vitro E.coli expression system |
| CSB-MP005506HU | Recombinant Human Claudin-4 (CLDN4)-VLPs (Active) | Mammalian cell |
CLDN4 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP005506MO1 CSB-EP005506MO1 CSB-BP005506MO1 CSB-MP005506MO1 CSB-EP005506MO1-B |
Recombinant Mouse Claudin-4 (Cldn4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF005506MO | Recombinant Mouse Claudin-4 (Cldn4) | in vitro E.coli expression system |
CLDN4 Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP005506DSU1 CSB-EP005506DSU1 CSB-BP005506DSU1 CSB-MP005506DSU1 CSB-EP005506DSU1-B |
Recombinant Chlorocebus aethiops Claudin-4 (CLDN4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF005506DSU | Recombinant Chlorocebus aethiops Claudin-4 (CLDN4) | in vitro E.coli expression system |
CLDN4 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP718376BO1 CSB-EP718376BO1 CSB-BP718376BO1 CSB-MP718376BO1 CSB-EP718376BO1-B |
Recombinant Bovine Claudin-4 (CLDN4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF718376BO | Recombinant Bovine Claudin-4 (CLDN4) | in vitro E.coli expression system |
CLDN4 ELISA Kit
CLDN4 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E17961h | Human Claudin 4 (CLDN4)ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 1.56 pg/mL |
