CHRNA4
CHRNA4全稱為神經元煙堿型乙酰膽堿受體的α4亞基,常被稱為nAChR α4或CHRN4。這類受體廣泛分布于中樞神經系統,尤其在丘腦和前額葉皮層中富集,通過結合乙酰膽堿參與神經信號的傳遞,調控注意力、記憶及覺醒狀態。CHRNA4功能異常與多種神經系統疾病密切相關,例如某些家族性夜間額葉癲癇患者的突變位點常出現在該基因區域,導致神經元興奮性失衡。此外,該受體還涉及尼古丁成癮機制,吸煙者體內長期尼古丁刺激可能引發受體脫敏,形成依賴性。帕金森病、阿爾茨海默病等神經退行性疾病中也觀察到該受體表達水平的變化。近年來,針對α4亞基的藥物研究集中在精神類疾病和戒斷治療領域,例如部分抗癲癇藥物通過增強受體功能緩解癥狀,而伐尼克蘭等戒煙藥物則通過部分激活受體降低尼古丁渴求。不過,由于該受體在中樞的多重調控作用,藥物研發需平衡療效與副作用風險,目前尚無雙靶點特異性藥物進入臨床后期階段。
熱銷產品
CHRNA4 Antibody (CSB-PA215866)
驗證數據

The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA215866(CHRNA4 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA215866(CHRNA4 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)

Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Lovo cells, 293T cells, Primary antibody: CSB-PA215866(CHRNA4 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
CHRNA4 Antibodies
CHRNA4 for Homo sapiens (Human)
產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
---|---|---|---|
CSB-PA938221 | CHRNA4 Antibody | Human | ELISA,IHC |
CSB-PA215866 | CHRNA4 Antibody | Human | ELISA,WB,IHC |
CHRNA4 Proteins
CHRNA4 Proteins for Homo sapiens (Human)
產品貨號 | 產品名稱 | 來源 |
---|---|---|
CSB-YP005390HU CSB-EP005390HU CSB-BP005390HU CSB-MP005390HU CSB-EP005390HU-B |
Recombinant Human Neuronal acetylcholine receptor subunit alpha-4 (CHRNA4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |