CHEK2
Serine/threonine-protein kinase Chk2 is a protein in humans that is encoded by CHEK2 gene. Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression.
CHEK2 Antibodies
CHEK2 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA005339GA01HU | CHEK2 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA440208 | Phospho-CHEK2 (Ser516) Antibody | Human | ELISA,WB |
| CSB-PA074742 | CHEK2 (Ab-516) Antibody | Human | ELISA,WB |
| CSB-PA983913 | Phospho-CHEK2 (Thr387) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA159350 | Phospho-CHEK2 (Thr383) Antibody | Human,Mouse,Rat | ELISA,WB,IF |
| CSB-PA884585 | CHEK2 (Ab-68) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA000499 | Phospho-CHEK2 (S516) Antibody | Human,Monkey | WB, ELISA |
| CSB-PA000500 | Phospho-CHEK2 (T68) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA001630 | CHEK2 Antibody | Human | WB, ELISA |
| CSB-PA001634 | CHEK2 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA006786 | Phospho-CHEK2 (T383) Antibody | Human,Mouse,Rat,Monkey | WB, IF, ELISA |
| CSB-PA006787 | Phospho-CHEK2 (T387) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA006788 | CHEK2 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA006789 | CHEK2 Antibody | Human,Mouse,Rat,Monkey | WB, IHC, ELISA |
| CSB-PA187496 | CHEK2 Antibody | Human | ELISA,WB |
| CSB-PA005339LA01HU | CHEK2 Antibody | Human | ELISA, IHC |
CHEK2 Proteins
CHEK2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP005339HU CSB-EP005339HU CSB-BP005339HU CSB-MP005339HU CSB-EP005339HU-B |
Recombinant Human Serine/threonine-protein kinase Chk2 (CHEK2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
