CD48
CD48（又稱BLAST-1或SLAMF2）為糖基磷脂酰肌醇（GPI）連接的免疫球蛋白超家族成員。CD48作為一個免疫共刺激分子和黏附分子，參與免疫性疾病的調(diào)控。人CD48基因定位于染色體1q21-23，其編碼產(chǎn)物為一種糖蛋白，分子量約為45kD。CD48表達于NK細胞、T細胞、單核細胞和嗜堿性粒細胞表面，參與這些細胞的粘附和活化途徑。CD48表達在炎性條件下會增加。研究發(fā)現(xiàn)當IFN-α、IFN-β、IFN-γ等細胞因子暴露時，可增加人外周血單核細胞CD48的表達。CD48的配體主要有CD2，CD244，F(xiàn)imH。CD48與多種配體結(jié)合，它的激活會引起脂質(zhì)筏中信號因子的重新排列、Lck激酶的活性以及酪氨酸磷酸化，從而發(fā)揮不同的免疫功能。大量研究表明，CD48在B和T淋巴細胞、NK細胞、肥大細胞和嗜酸性粒細胞中參與免疫調(diào)節(jié)機制，在自身免疫、炎癥、過敏、造血以及腫瘤中的發(fā)揮重要的作用。
Recombinant Human CD48 活性蛋白實驗驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Measured by its binding ability in a functional ELISA. Immobilized CD48 at 2 μg/ml can bind Anti-CD48 rabbit monoclonal antibody, the EC50 of human CD48 protein is 0.5806-0.8463 ng/ml.
CD48 Antibodies
CD48 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA004941GA01HU | CD48 Antibody | Human | ELISA |
| CSB-PA004941ESR1HU | CD48 Antibody | Human | ELISA, IHC |
| CSB-PA004941ESR2HU | CD48 Antibody | Human, Mouse | ELISA, WB |
| CSB-PA005223 | CD48 Antibody | Human | WB, ELISA |
| CSB-PA074453 | CD48 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA183273 | CD48 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-RA178195A0HU | CD48 Recombinant Monoclonal Antibody | Human | ELISA, WB |
| CSB-MA004941A0m | CD48 Monoclonal Antibody | Human, Mouse | ELISA, WB, IF, FC |
| CSB-MA004941A1m | CD48 Monoclonal Antibody | Human, Mouse | ELISA, WB, IF, FC |
CD48 Proteins
CD48 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004941RA CSB-EP004941RA CSB-BP004941RA CSB-MP004941RA CSB-EP004941RA-B |
Recombinant Rat CD48 antigen (Cd48) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD48 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004941MO CSB-EP004941MO CSB-BP004941MO CSB-MP004941MO CSB-EP004941MO-B |
Recombinant Mouse CD48 antigen (Cd48) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD48 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004941HU | Recombinant Human CD48 antigen (CD48) | Yeast |
| CSB-EP004941HU CSB-BP004941HU CSB-EP004941HU-B |
Recombinant Human CD48 antigen (CD48) | E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP004941HU | Recombinant Human CD48 antigen (CD48) (Active) | Mammalian cell |
CD48 ELISA Kit
CD48 ELISA Kit for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL004941MO | Mouse CD48 antigen(CD48) ELISA kit | Request Information |
