CD147

CD147，（也稱為Basigin或EMMPRIN），是一種跨膜蛋白，屬于免疫球蛋白超家族，其結(jié)構(gòu)含有一個(gè)細(xì)胞外N端和一個(gè)胞內(nèi)C端。它有一個(gè)Ig-like（免疫球蛋白樣）細(xì)胞外結(jié)構(gòu)域，可與其他蛋白質(zhì)發(fā)生相互作用。CD147廣泛表達(dá)在許多細(xì)胞類型中，包括免疫細(xì)胞、白血球、紅血球、神經(jīng)細(xì)胞、膠質(zhì)細(xì)胞、腫瘤細(xì)胞等。它在細(xì)胞間黏附和遷移過程中發(fā)揮重要作用，并參與多種生物學(xué)過程，如細(xì)胞的增殖、侵襲、轉(zhuǎn)移以及免疫細(xì)胞的活化和炎癥反應(yīng)等。在腫瘤學(xué)中，CD147被認(rèn)為是一種腫瘤相關(guān)標(biāo)志物，因?yàn)樗诙喾N腫瘤細(xì)胞表面的表達(dá)水平明顯升高，與腫瘤細(xì)胞的侵襲和轉(zhuǎn)移有關(guān)。CD147還參與調(diào)節(jié)腫瘤微環(huán)境中的細(xì)胞間相互作用，對(duì)腫瘤的生長和進(jìn)展具有一定的影響。此外，CD147在免疫調(diào)節(jié)和感染過程中也發(fā)揮著重要作用。它與病原體感染、炎癥反應(yīng)和免疫細(xì)胞的活化和遷移等過程密切相關(guān)。是疾病治療和新藥開發(fā)的潛在靶點(diǎn)。

熱銷產(chǎn)品

● Recombinant Human Basigin(BSG),partial (Active)

驗(yàn)證數(shù)據(jù)

High Purity Validated by SDS-PAGE

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Excellent Bioactivity Validated by Functional ELISA

Activity: Measured by its binding ability in a functional ELISA. Immobilized CD147 at 2 μg/ml can bind Anti-CD147 recombinant Antibody, the EC₅₀ is 21.95-33.12 ng/ml.

● CD147 Recombinant Monoclonal Antibody CSB-RA002831A0HU

驗(yàn)證數(shù)據(jù)

Western Blot

Positive WB detected in: HepG2 whole cell lysate, ntera2 whole cell lysate, A549 whole cell lysate, U251 whole cell lysate

All lanes: CD147 antibody at 1:1000

Secondary

Goat polyclonal to mouse IgG at 1/50000 dilution

Predicted band size: 42, 29, 23, 19 KDa

Observed band size: 35, 50-60 KDa

CD147 Antibody

CD147 Protein

CD147 ELISA Kit

CD147 Antibodies

CD147 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA11759A0Rb	BSG Antibody	Human	ELISA, WB, IHC
CSB-PA11759C0Rb	BSG Antibody, FITC conjugated	Human
CSB-PA002831GA01HU	BSG Antibody	Human	ELISA,WB,IHC
CSB-PA11759B0Rb	BSG Antibody, HRP conjugated	Human	ELISA
CSB-PA11759D0Rb	BSG Antibody, Biotin conjugated	Human	ELISA
CSB-PA002331	BSG Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA005853	BSG Antibody	Human	WB, ELISA
CSB-PA993569	BSG Antibody	Human	ELISA,IHC
CSB-PA570608	BSG Antibody	Human	ELISA,WB,IHC
CSB-RA002831A0HU	CD147 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, IF, FC

CD147 Proteins

CD147 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP002831MO1 CSB-EP002831MO1 CSB-BP002831MO1 CSB-MP002831MO1 CSB-EP002831MO1-B	Recombinant Mouse Basigin (Bsg), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF002831MO	Recombinant Mouse Basigin (Bsg)	in vitro E.coli expression system

CD147 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP002831HU CSB-EP002831HU CSB-BP002831HU CSB-EP002831HU-B	Recombinant Human Basigin (BSG), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-EP002831HU2	Recombinant Human Basigin (BSG), partial	E.coli
CSB-CF002831HU	Recombinant Human Basigin (BSG)	in vitro E.coli expression system
CSB-MP002831HU	Recombinant Human Basigin (BSG), partial	Mammalian cell
CSB-MP002831HUf3	Recombinant Human Basigin (BSG), partial	Mammalian cell
CSB-MP002831HU1	Recombinant Human Basigin (BSG), partial (Active)	Mammalian cell

CD147 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP002831RA1 CSB-EP002831RA1 CSB-BP002831RA1 CSB-MP002831RA1 CSB-EP002831RA1-B	Recombinant Rat Basigin (Bsg), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF002831RA	Recombinant Rat Basigin (Bsg)	in vitro E.coli expression system

CD147 Proteins for Oryctolagus cuniculus (Rabbit)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP631727RB CSB-EP631727RB CSB-BP631727RB CSB-MP631727RB CSB-EP631727RB-B	Recombinant Rabbit Basigin (BSG), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

CD147 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來源
CSB-YP857519DXU CSB-EP857519DXU CSB-BP857519DXU CSB-MP857519DXU CSB-EP857519DXU-B	Recombinant Cricetulus griseus Basigin (BSG), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli