CD14
CD14，全稱為單核細胞分化抗原CD14，也被稱作MY23、LeuM3或p55，是一種主要分布于單核細胞、巨噬細胞及中性粒細胞表面的糖蛋白。CD14作為脂多糖（LPS）的高親和力受體，能夠識別并結(jié)合細菌內(nèi)毒素，通過與TLR4受體形成復合物激活下游免疫應答。在感染過程中，CD14通過TLR4/MyD88依賴的信號通路觸發(fā)NF-κB等轉(zhuǎn)錄因子活化，誘導TNF-α、IL-6等促炎因子釋放，參與膿毒癥、慢性炎癥性疾病的發(fā)展。臨床研究發(fā)現(xiàn)，CD14基因多態(tài)性與動脈粥樣硬化、阿爾茨海默病及類風濕性關節(jié)炎等疾病風險相關，其表達水平在膿毒癥患者血液中顯著升高，已成為感染性休克的潛在生物標志物。針對CD14的抗體藥物（如IC14）已進入臨床試驗階段，用于中和內(nèi)毒素引發(fā)的過度炎癥反應，同時基于TLR4-CD14信號軸的小分子抑制劑也在探索治療自身免疫性疾病的新策略。
熱銷產(chǎn)品
Recombinant Human Monocyte differentiation antigen CD14 (CD14), partial (Active) (CSB-MP004879HU1)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CD14 at 2 μg/ml on an Nickel Coated plate can bind Anti-CD14 recombinant antibody (CSB-RA004879MA1HU). The EC50 is 2.148-2.447 ng/mL.
Recombinant Human Monocyte differentiation antigen CD14 (CD14) (CSB-EP004879HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CD14 Recombinant Monoclonal Antibody (CSB-RA004879MA1HU)
驗證數(shù)據(jù)
IHC image of CSB-RA004879MA1HU diluted at 1：100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.
The Binding Activity of Human CD14 with Anti-CD14 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD14 (CSB-MP004879HU1) at 2 μg/mL on an Nickel Coated plate can bind Anti-CD14 recombinant antibody. The EC50 is 2.148-2.447 ng/mL.
Human soluble cluster of differentiation 14,sCD14 ELISA Kit (CSB-E13199h)
驗證數(shù)據(jù)
貨號：CSB-E13199h
規(guī)格：96T/48T
靈敏度：0.229 ng/mL
檢測范圍：0.234 ng/mL-15 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
CD14 Antibodies
CD14 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA004879GA01HU | CD14 Antibody | Human | ELISA,WB,IHC |
| CSB-MA004879A0m | CD14 Monoclonal Antibody | Human, Mouse, Rabbit | ELISA, WB, IF, FC |
| CSB-PA07085A0Rb | CD14 Antibody | Human | ELISA, IHC, IF |
| CSB-PA07085B0Rb | CD14 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA07085C0Rb | CD14 Antibody, FITC conjugated | Human | |
| CSB-PA07085D0Rb | CD14 Antibody, Biotin conjugated | Human | ELISA |
| CSB-MA004879A1m | CD14 Monoclonal Antibody | Human, Mouse, Rat, Rabbit | ELISA, WB, IF |
| CSB-MA792948 | CD14 Monoclonal Antibody | Human | ELISA, IHC |
| CSB-RA004879MA1HU | CD14 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
CD14 Proteins
CD14 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004879MO CSB-EP004879MO CSB-BP004879MO CSB-MP004879MO CSB-EP004879MO-B |
Recombinant Mouse Monocyte differentiation antigen CD14 (Cd14) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD14 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004879HU CSB-BP004879HU CSB-EP004879HU-B |
Recombinant Human Monocyte differentiation antigen CD14 (CD14) | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP004879HU | Recombinant Human Monocyte differentiation antigen CD14 (CD14) | E.coli |
| CSB-MP004879HU | Recombinant Human Monocyte differentiation antigen CD14 (CD14) | Mammalian cell |
| CSB-MP004879HU1 | Recombinant Human Monocyte differentiation antigen CD14 (CD14), partial (Active) | Mammalian cell |
CD14 Proteins for Oryctolagus cuniculus (Rabbit)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP638942RB CSB-EP638942RB CSB-BP638942RB CSB-MP638942RB CSB-EP638942RB-B |
Recombinant Rabbit Monocyte differentiation antigen CD14 (CD14) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD14 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP737216RA CSB-EP737216RA CSB-BP737216RA CSB-MP737216RA CSB-EP737216RA-B |
Recombinant Rat Monocyte differentiation antigen CD14 (Cd14) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD14 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP839154BO CSB-EP839154BO CSB-BP839154BO CSB-MP839154BO CSB-EP839154BO-B |
Recombinant Bovine Monocyte differentiation antigen CD14 (CD14) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD14 ELISA Kit
CD14 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E13199h | Human soluble cluster of differentiation 14,sCD14 ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates, urine | 0.229 ng/mL |
CD14 ELISA Kit for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E11178r | Rat soluble cluster of differentiation 14,sCD14 ELISA Kit | serum, plasma, tissue homogenates | 7 ng/mL |
