CCR2

C-C趨化因子受體2型（CCR2）是免疫系統(tǒng)中重要的信號傳導(dǎo)蛋白，因其與CD192、ChemR13等別名廣為人知。該受體主要分布于單核細(xì)胞、記憶T細(xì)胞表面，通過識別趨化因子CCL2等配體，引導(dǎo)免疫細(xì)胞向炎癥或損傷部位定向遷移。CCR2的異常激活與多種疾病密切相關(guān)，例如動脈粥樣硬化斑塊中巨噬細(xì)胞浸潤、類風(fēng)濕性關(guān)節(jié)炎的滑膜炎癥加劇，以及乳腺癌、胰腺癌的轉(zhuǎn)移過程均存在其活躍表達(dá)。近年來，針對CCR2的藥物開發(fā)成為熱點(diǎn)，輝瑞公司開發(fā)的INCB3344曾進(jìn)入銀屑病二期試驗(yàn)，而艾伯維的ABT-129則在糖尿病腎病研究中展現(xiàn)出調(diào)節(jié)免疫微環(huán)境的潛力。盡管部分候選藥物因療效不足或脫靶效應(yīng)終止研發(fā)，但新型雙靶點(diǎn)抑制劑（如同時(shí)阻斷CCR2/CCR5的cenicriviroc）在非酒精性脂肪性肝炎治療中取得積極數(shù)據(jù)，為慢性炎癥性疾病提供了新思路。

熱銷產(chǎn)品

Recombinant Human C-C chemokine receptor type 2 (CCR2) (Active) (CSB-CF004841HU)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CCR2 Recombinant Monoclonal Antibody (CSB-RA297464A0HU)

驗(yàn)證數(shù)據(jù)

IHC image of CSB-RA297464A0HU diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Human CC-Chemokine Receptor 2,CCR2 ELISA Kit (CSB-E14200h)

驗(yàn)證數(shù)據(jù)

貨號：CSB-E14200h

規(guī)格：96T/48T

靈敏度：5.86 pg/mL

檢測范圍：23.44 pg/mL-1500 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

CCR2 Antibody

CCR2 Protein

CCR2 ELISA Kit

CCR2 Antibodies

CCR2 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA004841GA01HU	CCR2 Antibody	Human	ELISA,WB
CSB-PA006295	CCR2 Antibody	Human	WB, ELISA
CSB-PA171419	CCR2 Antibody	Human,Mouse	ELISA,WB,IHC
CSB-PA004841LA01HU	CCR2 Antibody	Human	ELISA, IF
CSB-RA297464A0HU	CCR2 Recombinant Monoclonal Antibody	Human	ELISA, IHC

CCR2 for Rattus norvegicus (Rat)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA006349	CCR2 Antibody	Rat, Human	WB, IF, ELISA

CCR2 Proteins

CCR2 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004841HU1 CSB-EP004841HU1 CSB-BP004841HU1 CSB-MP004841HU1 CSB-EP004841HU1-B	Recombinant Human C-C chemokine receptor type 2 (CCR2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF004841HU	Recombinant Human C-C chemokine receptor type 2 (CCR2) (Active)	in vitro E.coli expression system
CSB-MP004841HU	Recombinant Human C-C chemokine receptor type 2 (CCR2)-VLPs	Mammalian cell

CCR2 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004841MO1 CSB-BP004841MO1 CSB-MP004841MO1 CSB-EP004841MO1-B	Recombinant Mouse C-C chemokine receptor type 2 (Ccr2), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF004841MO	Recombinant Mouse C-C chemokine receptor type 2 (Ccr2)	in vitro E.coli expression system

CCR2 Proteins for Macaca mulatta (Rhesus macaque)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004841MOW1 CSB-EP004841MOW1 CSB-BP004841MOW1 CSB-MP004841MOW1 CSB-EP004841MOW1-B	Recombinant Macaca mulatta (Rhesus macaque) C-C chemokine receptor type 2 (CCR2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF004841MOW	Recombinant Macaca mulatta (Rhesus macaque) C-C chemokine receptor type 2 (CCR2)	in vitro E.coli expression system

CCR2 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004841RA1 CSB-EP004841RA1 CSB-BP004841RA1 CSB-MP004841RA1 CSB-EP004841RA1-B	Recombinant Rat C-C chemokine receptor type 2 (Ccr2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF004841RA	Recombinant Rat C-C chemokine receptor type 2 (Ccr2)	in vitro E.coli expression system

CCR2 Proteins for Arabidopsis thaliana (Mouse-ear cress)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP525710DOA CSB-EP525710DOA CSB-BP525710DOA CSB-MP525710DOA CSB-EP525710DOA-B	Recombinant Arabidopsis thaliana Serine/threonine-protein kinase-like protein CCR2 (CCR2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli