CCL5
CCL5全稱為C-C基序趨化因子配體5，又稱RANTES（調節激活正常T細胞表達和分泌因子），是免疫系統重要的信號分子。CCL5主要由T淋巴細胞、血小板和某些上皮細胞分泌，能夠招募單核細胞、嗜酸性粒細胞等免疫細胞向炎癥部位聚集。通過與細胞表面CCR1、CCR3和CCR5等受體結合，不僅參與抗病毒免疫反應，還與HIV病毒利用CCR5共受體入侵細胞的過程密切相關。在病理狀態下，CCL5過度表達與類風濕性關節炎、動脈粥樣硬化等慢性炎癥疾病相關，同時被發現能通過調控腫瘤微環境促進乳腺癌、肺癌等惡性腫瘤的轉移。
近年針對CCL5及其受體的藥物開發取得進展，抗HIV藥物馬拉維諾正是通過阻斷CCR5受體發揮作用。在癌癥治療領域，多個臨床前研究證實抑制CCL5可降低腫瘤侵襲性，相關單克隆抗體藥物已進入Ⅰ期臨床試驗。由于CCL5在抗感染與促腫瘤中存在雙重作用，其靶向治療需精準調控表達水平，目前科研團隊正探索基于納米載體的局部遞送系統以平衡療效與安全性。
熱銷產品
Recombinant Human C-C motif chemokine 5 (CCL5) (CSB-EP004800HUc7)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CCL5 Antibody (CSB-PA05955A0Rb)
驗證數據
Western blot
All lanes: CCL5 antibody at 2µg/ml
Lane 1: EC109 whole cell lysate
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/15000 dilution
Predicted band size: 10 kDa
Observed band size: 70 kDa
CCL5 Antibodies
CCL5 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA05955A0Rb | CCL5 Antibody | Human | ELISA, WB |
| CSB-PA05955B0Rb | CCL5 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA05959A0Rb | CCL5 Antibody | Human | ELISA, WB |
| CSB-PA040300 | CCL5 Antibody | Human,Mouse,Rat | IHC, ELISA |
CCL5 Proteins
CCL5 Proteins for Cavia porcellus (Guinea pig)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP004800GU CSB-EP004800GU CSB-BP004800GU CSB-MP004800GU CSB-EP004800GU-B |
Recombinant Guinea pig C-C motif chemokine 5 (CCL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP004800HU CSB-BP004800HU CSB-MP004800HU CSB-EP004800HU-B |
Recombinant Human C-C motif chemokine 5 (CCL5) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP004800HUe0 | Recombinant Human C-C motif chemokine 5 (CCL5) | E.coli |
| CSB-EP004800HU | Recombinant Human C-C motif chemokine 5 (CCL5) | E.coli |
| CSB-AP000871HU | Recombinant Human C-C motif chemokine 5 protein (CCL5) | E.Coli |
| CSB-EP004800HUc7 | Recombinant Human C-C motif chemokine 5 (CCL5) | E.coli |
| CSB-EP004800HUg5 | Recombinant Human C-C motif chemokine 5 (CCL5) | E.coli |
| CSB-EP004800HUd7 | Recombinant Human C-C motif chemokine 5 (CCL5) | E.coli |
CCL5 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP004800MO CSB-EP004800MO CSB-BP004800MO CSB-MP004800MO CSB-EP004800MO-B |
Recombinant Mouse C-C motif chemokine 5 (Ccl5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-AP001241MO | Recombinant Mouse C-C motif chemokine 5 protein (Ccl5) | E.Coli |
CCL5 Proteins for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP004800RA CSB-EP004800RA CSB-BP004800RA CSB-MP004800RA CSB-EP004800RA-B |
Recombinant Rat C-C motif chemokine 5 (Ccl5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP004800BO CSB-EP004800BO CSB-BP004800BO CSB-MP004800BO CSB-EP004800BO-B |
Recombinant Bovine C-C motif chemokine 5 (CCL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 Proteins for Sus scrofa (Pig)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP643672PI CSB-EP643672PI CSB-BP643672PI CSB-MP643672PI CSB-EP643672PI-B |
Recombinant Pig C-C motif chemokine 5 (CCL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP808495DO CSB-EP808495DO CSB-BP808495DO CSB-MP808495DO CSB-EP808495DO-B |
Recombinant Dog C-C motif chemokine 5 (CCL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 Proteins for Macaca mulatta (Rhesus macaque)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP814163MOW CSB-EP814163MOW CSB-BP814163MOW CSB-MP814163MOW CSB-EP814163MOW-B |
Recombinant Macaca mulatta C-C motif chemokine 5 (CCL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 Proteins for Sigmodon hispidus (Hispid cotton rat)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP842062SZK CSB-EP842062SZK CSB-BP842062SZK CSB-MP842062SZK CSB-EP842062SZK-B |
Recombinant Sigmodon hispidus C-C motif chemokine 5 (CCL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 Proteins for Felis catus (Cat) (Felis silvestris catus)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP844627CA CSB-EP844627CA CSB-BP844627CA CSB-MP844627CA CSB-EP844627CA-B |
Recombinant Cat C-C motif chemokine 5 (CCL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 Proteins for Equus caballus (Horse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP847581HO CSB-EP847581HO CSB-BP847581HO CSB-MP847581HO CSB-EP847581HO-B |
Recombinant Horse C-C motif chemokine 5 (CCL5) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CCL5 ELISA Kit
CCL5 ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL004800DO | Dog C-C motif chemokine 5(CCL5) ELISA kit | serum, plasma, tissue homogenates | 0.081 ng/mL |
CCL5 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E17375h | Human C-C motif chemokine 5 (CCL5/D17S136E/SCYA5) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 2.307 pg/mL |
CCL5 ELISA Kit for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E09256m | Mouse regulated on activation in normal T-cell expressed and secreted,RANTES ELISA kit | serum, plasma, tissue homogenates | 0.039 ng/mL |
CCL5 ELISA Kit for Rattus norvegicus (Rat)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E07398r | Rat regulated on activation in normal T-cell expressed and secreted/C-C motif chemokine 5 (RANTES/CCL5) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 0.039 ng/mL |
