CBLC
E3 ubiquitin-protein ligase CBL-C is a protein in humans that is encoded by CBLC gene. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.
CBLC Antibodies
CBLC for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA004580GA01HU | CBLC Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA892346ESR1HU | CBLC Antibody | Human | ELISA, IHC |
| CSB-PA892346ESR2HU | CBLC Antibody | Human | ELISA, WB, IHC |
CBLC Proteins
CBLC Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP768908MO CSB-EP768908MO CSB-BP768908MO CSB-MP768908MO CSB-EP768908MO-B |
Recombinant Mouse Signal transduction protein CBL-C (Cblc) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CBLC Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP892346HU CSB-EP892346HU CSB-BP892346HU CSB-MP892346HU CSB-EP892346HU-B |
Recombinant Human Signal transduction protein CBL-C (CBLC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
