CBFB
Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation.
CBFB Antibodies
CBFB for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA004577GA01HU | CBFB Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA623835ESR1HU | CBFB Antibody | Human | ELISA, IHC |
| CSB-PA107678 | CBFB Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA003737 | CBFB Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA623835LA01HU | CBFB Antibody | Human | ELISA |
CBFB Proteins
CBFB Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP623835HU CSB-BP623835HU CSB-MP623835HU CSB-EP623835HU-B |
Recombinant Human Core-binding factor subunit beta (CBFB) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP623835HU | Recombinant Human Core-binding factor subunit beta (CBFB) | E.coli |
