CASR
CASR，即鈣敏感受體，別名包括CAR、PCaR1。它是一種C家族GPCR（G蛋白偶聯(lián)受體），主要分布在人體的甲狀腺、甲狀旁腺、骨骼、腸道系統(tǒng)以及腎臟等器官中。CASR的作用機制是通過感應(yīng)鈣離子濃度變化，調(diào)節(jié)體內(nèi)鈣離子平衡，其失活性突變會引起高血鈣疾病，而激活性突變會引起低血鈣疾病。此外，CASR也能感應(yīng)多種內(nèi)源性物質(zhì)，如氨基酸、氨基酸衍生物、多肽以及多胺化合物等。CASR在維持人體鈣離子平衡和骨代謝中發(fā)揮著重要作用，是重要的藥物靶標，相關(guān)研究已取得重要進展，為理解其激活機制和藥物研發(fā)提供了結(jié)構(gòu)基礎(chǔ)。
熱銷產(chǎn)品
Recombinant Human Extracellular calcium-sensing receptor (CASR), partial (CSB-YP004558HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CASR Antibodies
CASR for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA004558GA01HU | CASR Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA004558EC01HU | CASR Antibody, FITC conjugated | Human | |
| CSB-PA004558EA01HU | CASR Antibody | Human | ELISA, IF |
| CSB-PA004558EB01HU | CASR Antibody, HRP conjugated | Human | ELISA |
| CSB-PA443839 | CASR Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA446768 | Phospho-CASR (Thr888) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA070030 | Phospho-CASR (T888) Antibody | Human,Mouse,Rat | WB, IF, ELISA |
| CSB-PA070031 | CASR Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA080191 | CASR Antibody | Mouse,Rat | WB, IHC |
CASR Proteins
CASR Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004558BO CSB-EP004558BO CSB-BP004558BO CSB-MP004558BO CSB-EP004558BO-B |
Recombinant Bovine Extracellular calcium-sensing receptor (CASR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CASR Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004558HU | Recombinant Human Extracellular calcium-sensing receptor (CASR), partial | Yeast |
| CSB-EP004558HU | Recombinant Human Extracellular calcium-sensing receptor (CASR), partial | E.coli |
| CSB-BP004558HU CSB-MP004558HU CSB-EP004558HU-B |
Recombinant Human Extracellular calcium-sensing receptor (CASR), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CASR Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004558RA CSB-EP004558RA CSB-BP004558RA CSB-MP004558RA CSB-EP004558RA-B |
Recombinant Rat Extracellular calcium-sensing receptor (Casr), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CASR Proteins for Sus scrofa (Pig)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004558PI1 CSB-EP004558PI1 CSB-BP004558PI1 CSB-MP004558PI1 CSB-EP004558PI1-B |
Recombinant Pig Extracellular calcium-sensing receptor (CASR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CASR Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP874122MO CSB-EP874122MO CSB-BP874122MO CSB-MP874122MO CSB-EP874122MO-B |
Recombinant Mouse Extracellular calcium-sensing receptor (Casr), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
