CASP8
Caspase-8 is a protein in humans that is encoded by CASP8 gene. Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein.
CASP8 Antibodies
CASP8 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA18109B0Rb | CASP8 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA004553GA01HU | CASP8 Antibody | Human | ELISA,WB,IHC |
| CSB-PA18109A0Rb | CASP8 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA982156 | CASP8 Antibody | Human | ELISA,WB |
| CSB-PA000009 | Cleaved-CASP8 (D384) Antibody | Human | WB, ELISA |
| CSB-PA000653 | Phospho-CASP8 (Y380) Antibody | Human | WB, ELISA |
| CSB-PA001234 | CASP8 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA060299 | Phospho-CASP8 (S347) Antibody | Human,Rat | WB, IHC, ELISA |
| CSB-PA080234 | CASP8 Antibody | Human,Mouse,Rat | WB, IHC |
CASP8 for Human, Mouse, Rat
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-MA080171 | CASP8 Monoclonal Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CASP8 Proteins
CASP8 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP004553MO CSB-EP004553MO CSB-BP004553MO CSB-MP004553MO CSB-EP004553MO-B |
Recombinant Mouse Caspase-8 (Casp8) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CASP8 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-BP621791HU CSB-MP621791HU CSB-EP621791HU-B |
Recombinant Human Caspase-8 (CASP8), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP621791HU | Recombinant Human Caspase-8 (CASP8), partial | E.coli |
CASP8 ELISA Kit
CASP8 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E13636h | Human Caspase 8(Casp-8) ELISA Kit | serum, plasma, cell lysates | 7.81 pg/mL |
