CAP1

CAP1，全稱為 Adenylyl cyclase-associated protein 1，別名 CAP，是一種與細胞骨架動態(tài)調(diào)節(jié)相關(guān)的蛋白。研究發(fā)現(xiàn)，CAP1 蛋白在多種生物的進化過程中高度保守，提示其在細胞骨架調(diào)控中發(fā)揮著重要作用。CAP1 蛋白能夠結(jié)合游離的肌動蛋白單體，并加速肌動蛋白多聚化過程，從而影響細胞的遷移、增殖等生命活動。此外，CAP1 蛋白還與多種疾病的發(fā)生發(fā)展密切相關(guān)，例如動脈粥樣硬化、肺癌等。近年來，CAP1 蛋白成為疾病診斷和治療研究的潛在靶點。研究表明，CAP1 蛋白的表達水平與動脈粥樣硬化嚴重程度呈正相關(guān)，且在肺癌細胞中高表達，可能參與肺癌細胞的遷移和增殖。基于這些發(fā)現(xiàn)，針對 CAP1 蛋白的藥物研發(fā)正在積極開展，例如開發(fā) CAP1 抑制劑等，以期用于相關(guān)疾病的治療。

熱銷產(chǎn)品

Recombinant Human Adenylyl cyclase-associated protein 1 (CAP1) (CSB-EP004486HUc7)

驗證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

CAP1 Antibody (CSB-PA004486LA01HU)

驗證數(shù)據(jù)

Western Blot
Positive WB detected in: HepG2 whole cell lysate, Raji whole cell lysate, 293T whole cell lysate, K562 whole cell lysate, Hela whole cell lysate, Jurkat whole cell lysate
All lanes: CAP1 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 52 kDa
Observed band size: 52 kDa

IHC image of CSB-PA004486LA01HU diluted at 1:200 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA004486LA01HU diluted at 1:200 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of U251 cells with CSB-PA004486LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Human Adenylyl cyclase-associated protein 1(CAP1) ELISA kit (CSB-EL004486HU)

驗證數(shù)據(jù)

貨號：CSB-EL004486HU

規(guī)格：96T/48T

靈敏度：6.25 pg/mL

檢測范圍：25 pg/mL-1600 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

CAP1 Antibody

CAP1 Protein

CAP1 ELISA Kit

CAP1 Antibodies

CAP1 for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA004486GA01HU	CAP1 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA256310	CAP1 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA147089	CAP1 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA004486LA01HU	CAP1 Antibody	Human	ELISA, WB, IHC, IF

CAP1 Proteins

CAP1 Proteins for Homo sapiens (Human)

產(chǎn)品貨號	產(chǎn)品名稱	來源
CSB-YP004486HU CSB-EP004486HU CSB-BP004486HU CSB-MP004486HU CSB-EP004486HU-B	Recombinant Human Adenylyl cyclase-associated protein 1 (CAP1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP004486HUc7	Recombinant Human Adenylyl cyclase-associated protein 1 (CAP1)	E.coli