BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta is a protein in humans that is encoded by BUB1B gene. Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.
BUB1B Antibodies
BUB1B for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA002883GA01HU | BUB1B Antibody | Human,Mouse | ELISA,WB |
| CSB-PA001071 | BUB1B Antibody | Human,Mouse | WB, ELISA |
| CSB-PA002883LA01HU | BUB1B Antibody | Human | ELISA, IHC, IF, IP |
| CSB-RA263021A0HU | BUB1B Recombinant Monoclonal Antibody | Human | ELISA, WB, FC |
BUB1B Proteins
BUB1B Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP002883HU CSB-EP002883HU CSB-BP002883HU CSB-MP002883HU CSB-EP002883HU-B |
Recombinant Human Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
