BCL11B
BCL11B，即B細(xì)胞淋巴瘤/白血病11B基因，別名CTIP2、RIT1。BCL11B在T細(xì)胞發(fā)育和身份維持中有重要作用，最初被發(fā)現(xiàn)是輻射引發(fā)的T細(xì)胞淋巴瘤的潛在抑制因子。BCL11B的作用機(jī)制涉及抑制NuRD復(fù)合物和促進(jìn)β-catenin與TCF4的相互作用來激活Wnt信號(hào)，其表達(dá)直接被BMP信號(hào)所抑制。BCL11B在T細(xì)胞急性淋巴細(xì)胞白血病（T-ALL）中作為單倍劑量不足的抑癌因子，與其他致癌病變聯(lián)合發(fā)揮作用。BCL11B還與神經(jīng)發(fā)育有關(guān)，其在少突膠質(zhì)細(xì)胞分化過程中的表達(dá)降低，但對(duì)神經(jīng)元分化和中樞神經(jīng)系統(tǒng)的發(fā)育具有調(diào)節(jié)作用。BCL11B的異常表達(dá)與多種疾病相關(guān)，包括T-ALL和某些神經(jīng)發(fā)育障礙。
熱銷產(chǎn)品
Recombinant Human B-cell lymphoma/leukemia 11B (BCL11B), partial (CSB-EP880159HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
BCL11B Antibody (CSB-PA880159HA01HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA880159HA01HU at dilution of 1:300
BCL11B Antibodies
BCL11B for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA880159HA01HU | BCL11B Antibody | Human | ELISA, IHC |
| CSB-PA880159HC01HU | BCL11B Antibody, FITC conjugated | Human |
BCL11B Proteins
BCL11B Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP880159HU CSB-BP880159HU CSB-MP880159HU CSB-EP880159HU-B |
Recombinant Human B-cell lymphoma/leukemia 11B (BCL11B), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP880159HU | Recombinant Human B-cell lymphoma/leukemia 11B (BCL11B), partial | E.coli |
