APEX2
DNA-is a protein in humans that is encoded by APEX2 gene. Function as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes.
APEX2 Proteins
APEX2 Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP682700BO CSB-EP682700BO CSB-BP682700BO CSB-MP682700BO CSB-EP682700BO-B |
Recombinant Bovine DNA- (apurinic or apyrimidinic site) lyase 2 (APEX2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
APEX2 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP727875MO CSB-EP727875MO CSB-BP727875MO CSB-MP727875MO CSB-EP727875MO-B |
Recombinant Mouse DNA- (apurinic or apyrimidinic site) lyase 2 (Apex2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
APEX2 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP871392HU CSB-EP871392HU CSB-BP871392HU CSB-MP871392HU CSB-EP871392HU-B |
Recombinant Human DNA- (apurinic or apyrimidinic site) lyase 2 (APEX2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
