ANTXR1
ANTXR1全稱為炭疽毒素受體1（Anthrax Toxin Receptor 1），早期研究中被稱為腫瘤內(nèi)皮標(biāo)記物8（TEM8）。ANTXR1屬于Ⅰ型跨膜蛋白家族，通過特異性結(jié)合炭疽桿菌毒素的保護(hù)性抗原組分，介導(dǎo)毒素進(jìn)入宿主細(xì)胞，成為炭疽感染的關(guān)鍵分子靶點(diǎn)。近年來研究發(fā)現(xiàn)，TEM8在正常生理狀態(tài)下參與血管新生調(diào)控，其胞外段含有的血管性血友病因子A結(jié)構(gòu)域（VWA）可與膠原蛋白等細(xì)胞外基質(zhì)成分相互作用，影響內(nèi)皮細(xì)胞遷移和血管網(wǎng)絡(luò)形成。
在疾病領(lǐng)域，ANTXR1的異常表達(dá)與多種實(shí)體瘤密切相關(guān)，例如結(jié)直腸癌、乳腺癌中常出現(xiàn)蛋白高表達(dá)，可能通過促進(jìn)腫瘤血管生成加速癌癥進(jìn)展。臨床前研究表明，針對(duì)TEM8的單克隆抗體或小分子抑制劑可顯著抑制小鼠模型中腫瘤生長(zhǎng)和轉(zhuǎn)移。此外，ANTXR1突變與罕見的GAPO綜合征相關(guān)，表現(xiàn)為生長(zhǎng)遲緩、脫發(fā)及骨發(fā)育異常。目前基于該靶點(diǎn)的藥物研發(fā)主要集中在炭疽毒素中和劑和抗腫瘤生物制劑兩大方向，已有數(shù)款單抗藥物進(jìn)入Ⅰ/Ⅱ期臨床試驗(yàn)階段。
熱銷產(chǎn)品
Recombinant Human Anthrax toxin receptor 1 (ANTXR1), partial (CSB-YP001832HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ANTXR1 Antibody (CSB-PA001832ESR1HU)
驗(yàn)證數(shù)據(jù)
Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA001832ESR1HU at dilution of 1:100
Human anthrax toxin receptor 1(ANTXR1) ELISA kit (CSB-EL001832HU)
驗(yàn)證數(shù)據(jù)
貨號(hào)：CSB-EL001832HU
規(guī)格：96T/48T
靈敏度：15.6 pg/mL
檢測(cè)范圍：62.5 pg/mL-4000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
ANTXR1 Antibodies
ANTXR1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA001832GA01HU | ANTXR1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA001832ESR1HU | ANTXR1 Antibody | Human | ELISA, IHC |
| CSB-PA283852 | ANTXR1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA276953 | ANTXR1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
ANTXR1 Proteins
ANTXR1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP001832HU | Recombinant Human Anthrax toxin receptor 1 (ANTXR1), partial | Yeast |
| CSB-EP001832HU CSB-BP001832HU CSB-MP001832HU CSB-EP001832HU-B |
Recombinant Human Anthrax toxin receptor 1 (ANTXR1), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ANTXR1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP001832MO | Recombinant Mouse Anthrax toxin receptor 1 (Antxr1), partial | Yeast |
| CSB-EP001832MO | Recombinant Mouse Anthrax toxin receptor 1 (Antxr1), partial | E.coli |
| CSB-BP001832MO CSB-EP001832MO-B |
Recombinant Mouse Anthrax toxin receptor 1 (Antxr1), partial | Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP001832MO | Recombinant Mouse Anthrax toxin receptor 1 (Antxr1), partial | Mammalian cell |
ANTXR1 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP001832RA CSB-EP001832RA CSB-BP001832RA CSB-MP001832RA CSB-EP001832RA-B |
Recombinant Rat Anthrax toxin receptor 1 (Antxr1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ANTXR1 ELISA Kit
ANTXR1 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL001832HU | Human anthrax toxin receptor 1(ANTXR1) ELISA kit | serum, plasma, tissue homogenates | 15.6 pg/mL |
