AMBRA1
AMBRA1，即自噬和Beclin 1調(diào)節(jié)器1，別名DCAF3、WDR94。它是一種由人類基因編碼的蛋白，屬于自噬調(diào)節(jié)因子，在自噬體的形成過程中扮演重要角色。AMBRA1的作用機(jī)制涉及激活GTPase結(jié)合活性和泛素蛋白酶結(jié)合活性，參與巨自噬作用、正調(diào)節(jié)磷酸肌醇3-激酶活性，并響應(yīng)線粒體去極化。AMBRA1位于細(xì)胞質(zhì)中，并與線粒體共定位，是多系統(tǒng)萎縮的生物標(biāo)志物。AMBRA1參與控制蛋白周轉(zhuǎn)、神經(jīng)發(fā)育、細(xì)胞生存和增殖，與腫瘤進(jìn)展密切相關(guān)，其表達(dá)水平預(yù)測黑色素瘤對MAPK抑制劑的耐藥性，并且與神經(jīng)管缺陷有關(guān)。
熱銷產(chǎn)品
AMBRA1 Antibody (CSB-PA927593)
驗證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA927593(AMBRA1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA927593(AMBRA1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
AMBRA1 Antibodies
AMBRA1 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA001655GA01HU | AMBRA1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA883655ESR2HU | AMBRA1 Antibody | Human | ELISA |
| CSB-PA927593 | AMBRA1 Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA163788 | AMBRA1 Antibody | Human,Mouse | ELISA,IHC |
AMBRA1 Proteins
AMBRA1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP001655MO CSB-EP001655MO CSB-BP001655MO CSB-MP001655MO CSB-EP001655MO-B |
Recombinant Mouse Activating molecule in BECN1-regulated autophagy protein 1 (Ambra1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
AMBRA1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP883655HU CSB-EP883655HU CSB-BP883655HU CSB-MP883655HU CSB-EP883655HU-B |
Recombinant Human Activating molecule in BECN1-regulated autophagy protein 1 (AMBRA1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
