ALPL
ALPL（組織非特異性堿性磷酸酶，TNSALP）是一種廣泛存在于人體多種組織中的膜結(jié)合糖蛋白，具有多種生理功能。它是一種同源二聚體酶，由不同基因位點(diǎn)編碼，每個(gè)催化位點(diǎn)包含兩個(gè)鋅離子和一個(gè)鎂離子。ALPL在骨骼礦化過(guò)程中起到關(guān)鍵作用，通過(guò)水解有機(jī)磷酸酯和去除無(wú)機(jī)焦磷酸(PPi)來(lái)促進(jìn)正常骨骼的形成和維護(hù)。此外，它還參與胚胎發(fā)育、細(xì)胞生長(zhǎng)、細(xì)胞凋亡和細(xì)胞遷移等細(xì)胞事件的調(diào)節(jié)。盡管具體的信號(hào)通路未明確提及，但ALPL的功能表明它可能參與骨骼礦化、細(xì)胞信號(hào)傳導(dǎo)和細(xì)胞凋亡等信號(hào)通路。ALPL的異常表達(dá)或功能失調(diào)與多種疾病相關(guān)，如遺傳性低磷酸酯酶癥、某些類型的癌癥以及骨骼和牙齒的疾病，使其成為醫(yī)學(xué)研究中的關(guān)鍵靶點(diǎn)。
熱銷產(chǎn)品
ALPL Antibody (CSB-PA11999A0Rb)
驗(yàn)證數(shù)據(jù)
IHC image of CSB-PA11999A0Rb diluted at 1:100 and staining in paraffin-embedded human ovarian cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
ALPL Antibodies
ALPL for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA001631GA01HU | ALPL Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA11999A0Rb | ALPL Antibody | Human | ELISA, IHC |
| CSB-PA11999D0Rb | ALPL Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA177961 | ALPL Antibody | Human | ELISA,WB |
| CSB-PA001631ESR2HU | ALPL Antibody | Human | ELISA, IHC |
| CSB-PA006129 | ALPL Antibody | Human,Rat | WB, ELISA |
| CSB-PA008482 | ALPL Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA034215 | ALPL Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA228295 | ALPL Antibody | Human,Mouse,Rat | ELISA,IHC |
ALPL ELISA Kit
ALPL ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E09033h | Human bone alkaline phosphatase,BALP ELISA Kit | serum, plasma, tissue homogenates | 7.8 ng/ml. |
