ALOX12
Catalyzes the regio and stereo-specific incorporation of molecular oxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species. Mainly converts arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) to the specific bioactive lipid (12S)-hydroperoxyeicosatetraenoate/(12S)-HPETE. Through the production of bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It can also catalyze the epoxidation of double bonds of polyunsaturated fatty acids such as (14S)-hydroperoxy-docosahexaenoate/(14S)-HPDHA resulting in the formation of (13S,14S)-epoxy-DHA. Furthermore, it may participate in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs) like resolvin D5 ((7S,17S)-diHPDHA) and (7S,14S)-diHPDHA, that actively downregulate the immune response and have anti-aggregation properties with platelets.
ALOX12 Antibodies
ALOX12 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA001617LA01HU | ALOX12 Antibody | Human | ELISA, WB, IHC, IF |
ALOX12 Proteins
ALOX12 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP001617HU CSB-BP001617HU CSB-MP001617HU CSB-EP001617HU-B |
Recombinant Human Arachidonate 12-lipoxygenase, 12S-type (ALOX12) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP001617HU | Recombinant Human Arachidonate 12-lipoxygenase, 12S-type (ALOX12) | E.coli |
ALOX12 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP001617MO CSB-EP001617MO CSB-BP001617MO CSB-MP001617MO CSB-EP001617MO-B |
Recombinant Mouse Arachidonate 12-lipoxygenase, 12S-type (Alox12) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ALOX12 ELISA Kit
ALOX12 ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E16996h | Human Arachidonate 12-lipoxygenase, 12S-type (ALOX12/LOG12) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 0.31 ng/mL |
