AKT3
AKT3，即蛋白激酶Bγ，是蛋白激酶B家族的第三個成員。AKT3主要在大腦、睪丸以及某些類型的癌細(xì)胞中表達(dá)。其作用機制與AKT1和AKT2類似，通過與PI3K（磷脂酰肌醇3激酶）激活后產(chǎn)生的PIP3結(jié)合，被招募到細(xì)胞膜上，隨后被上游激酶如PDK1磷酸化激活。激活后的AKT3能夠磷酸化多種底物，包括促進(jìn)細(xì)胞存活的BAD蛋白、FOXO轉(zhuǎn)錄因子以及mTOR信號通路中的組件。AKT3參與的信號通路包括PI3K/AKT/mTOR通路，這一通路在細(xì)胞生長、代謝、存活和增殖中起著關(guān)鍵作用。AKT3還與神經(jīng)發(fā)育、突觸可塑性以及認(rèn)知功能相關(guān)。在生物學(xué)意義上，AKT3對于神經(jīng)系統(tǒng)的正常功能和發(fā)育至關(guān)重要。其異常表達(dá)或功能失調(diào)與多種疾病有關(guān)，包括神經(jīng)退行性疾病、精神疾病和某些類型的癌癥。AKT3的活性調(diào)節(jié)是當(dāng)前藥物開發(fā)和疾病治療研究的熱點領(lǐng)域。
熱銷產(chǎn)品
AKT3 Antibody (CSB-PA15929A0Rb)
驗證數(shù)據(jù)
Immunoprecipitating AKT3 in mouse brain whole cell lysate
Lane 1: Rabbit control IgG (1μg) instead of CSB-PA15929A0Rb in mouse brain whole cell lysate.
For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
Lane 2: CSB-PA15929A0Rb (6μg) + Mouse brain whole cell lysate (500μg)
Lane 3: Mouse brain whole cell lysate (10μg)
AKT3 Antibodies
AKT3 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA001556GA01HU | AKT3 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA000388 | AKT3 Antibody | Human,Mouse,Rat | WB |
| CSB-PA983294 | AKT3 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA775649 | AKT3 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA15929A0Rb | AKT3 Antibody | Human, Mouse | ELISA, IP |
| CSB-PA15929C0Rb | AKT3 Antibody, FITC conjugated | Human |
AKT3 Proteins
AKT3 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP723581RA CSB-EP723581RA CSB-BP723581RA CSB-MP723581RA CSB-EP723581RA-B |
Recombinant Rat RAC-gamma serine/threonine-protein kinase (Akt3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
AKT3 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP894361MO CSB-EP894361MO CSB-BP894361MO CSB-MP894361MO CSB-EP894361MO-B |
Recombinant Mouse RAC-gamma serine/threonine-protein kinase (Akt3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
