ADAR
ADAR ，全稱為腺苷脫氨酶作用于RNA 1，是RNA編輯的關(guān)鍵酶，能夠?qū)NA分子中的腺苷（A）轉(zhuǎn)化為肌苷（I），從而影響RNA的功能和編碼的蛋白質(zhì)。ADAR 蛋白在多種生物學(xué)過(guò)程中發(fā)揮重要作用，包括免疫反應(yīng)、神經(jīng)功能和疾病的發(fā)生發(fā)展。ADAR 蛋白相關(guān)疾病包括Aicardi-Goutières綜合征（AGS）和遺傳性對(duì)稱性色素異常癥（DSH），這些疾病都與RNA編輯異常有關(guān)。目前，針對(duì)ADAR蛋白的藥物研發(fā)主要集中在RNA編輯療法，旨在通過(guò)精確修飾RNA序列來(lái)治療遺傳疾病和復(fù)雜疾病。例如，斯坦福大學(xué)生物學(xué)家李進(jìn)聯(lián)合創(chuàng)辦的RNA編輯療法公司AIRNA，正在開(kāi)發(fā)針對(duì)Alpha-1抗胰蛋白酶缺乏癥（AATD）的RNA編輯療法，計(jì)劃于2025年進(jìn)行I期臨床試驗(yàn)。此外，其他公司如Wave Life Sciences和Korro Bio也在積極開(kāi)發(fā)基于RNA編輯技術(shù)的藥物，為治療AATD等疾病帶來(lái)新的希望。
熱銷(xiāo)產(chǎn)品
Recombinant Human Double-stranded RNA-specific adenosine deaminase (ADAR), partial (CSB-EP001324HU)
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
ADAR Recombinant Monoclonal Antibody (CSB-RA906343A0HU)
驗(yàn)證數(shù)據(jù)
IHC image of CSB-RA906343A0HU diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
ADAR Antibodies
ADAR for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA001324GA01HU | ADAR Antibody | Human,Mouse,Rat,Pig | ELISA,WB,IHC,IF |
| CSB-PA006478 | ADAR Antibody | Human,Mouse,Rat | IHC, ELISA |
| CSB-PA790607 | ADAR Antibody | Human | ELISA,IHC |
| CSB-PA159695 | ADAR Antibody | Human | ELISA,IHC |
| CSB-PA001324LA01HU | ADAR Antibody | Human | ELISA, WB, IHC |
| CSB-PA001324LB01HU | ADAR Antibody, HRP conjugated | Human | ELISA |
| CSB-PA001324LC01HU | ADAR Antibody, FITC conjugated | Human | |
| CSB-PA001324LD01HU | ADAR Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA906343A0HU | ADAR Recombinant Monoclonal Antibody | Human | ELISA, IHC |
ADAR Proteins
ADAR Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP001324HU CSB-BP001324HU CSB-EP001324HU-B |
Recombinant Human Double-stranded RNA-specific adenosine deaminase (ADAR), partial | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP001324HU | Recombinant Human Double-stranded RNA-specific adenosine deaminase (ADAR), partial | E.coli |
| CSB-EP001324HUe0 | Recombinant Human Double-stranded RNA-specific adenosine deaminase (ADAR), partial | E.coli |
| CSB-MP001324HU | Recombinant Human Double-stranded RNA-specific adenosine deaminase (ADAR), partial | Mammalian cell |
| CSB-EP001324HUa0 | Recombinant Human Double-stranded RNA-specific adenosine deaminase (ADAR), partial | E.coli |
| CSB-EP001324HU2 | Recombinant Human Double-stranded RNA-specific adenosine deaminase (ADAR), partial | E.coli |
