ADAM9
ADAM9（A disintegrin and metalloprotease 9），即含有脫氨酸和金屬蛋白酶結(jié)構(gòu)域的蛋白9，是一種多功能的膜錨定蛋白，參與了多種生理過(guò)程。它由信號(hào)肽、金屬蛋白酶結(jié)構(gòu)域、脫氨酸結(jié)構(gòu)域、富含半胱氨酸的結(jié)構(gòu)域和類表皮生長(zhǎng)因子樣結(jié)構(gòu)域組成。ADAM9在高爾基體運(yùn)輸至細(xì)胞膜的過(guò)程中，通過(guò)去除其抑制性原結(jié)構(gòu)域而被激活，這一裂解過(guò)程由furin或前蛋白轉(zhuǎn)化酶在兩個(gè)PC位點(diǎn)進(jìn)行。ADAM9的功能涉及細(xì)胞粘附、細(xì)胞表面蛋白的脫落，以及在發(fā)育、炎癥和退行性疾病中的作用。特別地，ADAM9在腫瘤生物學(xué)中扮演著關(guān)鍵角色，其在多種癌癥中的過(guò)表達(dá)與腫瘤的侵襲性和不良預(yù)后密切相關(guān)。ADAM9通過(guò)蛋白水解和非蛋白水解途徑促進(jìn)腫瘤的進(jìn)展、治療抗性和轉(zhuǎn)移。它能夠識(shí)別并釋放膜結(jié)合的細(xì)胞因子和生長(zhǎng)因子的胞外片段，同時(shí)參與受體和其他分子的信號(hào)轉(zhuǎn)導(dǎo)。ADAM9在腫瘤增殖、血管生成和免疫逃逸等多個(gè)腫瘤過(guò)程中發(fā)揮作用。因此，ADAM9已成為炎癥性疾病和癌癥治療中的潛在生物標(biāo)志物和治療靶點(diǎn)，針對(duì)其的治療策略包括ADC藥物、單克隆抗體和小分子抑制劑等正在開(kāi)發(fā)中。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human ADAM9 at 2 μg/ml can bind Anti-ADAM9 recombinant antibody (CSB-RA618774MA1HU). The EC50 is 0.9401-1.088 ng/mL.
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA.Immobilized Macaca fascicularis ADAM9 at 2 μg/ml can bind Anti-ADAM9 recombinant antibody (CSB-RA618774MA1HU).The EC50 is 1.329-1.813 ng/mL.
ADAM9 Antibody (CSB-PA618774ESR1HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: Disintegrin and metalloproteinase domain-containing protein 9 antibody at 2μg/ml
Lane 1: Mouse liver tissue
Lane 2: Mouse heart tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 91, 73 kDa
Observed band size: 91 kDa
Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA618774ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA618774ESR1HU at dilution of 1:100
ADAM9 Antibodies
ADAM9 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA618774ESR1HU | ADAM9 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA618774ESR2HU | ADAM9 Antibody | Human | ELISA, IHC |
| CSB-RA618774MA1HU | ADAM9 (izeltabart) Recombinant Monoclonal Antibody | Human | ELISA |
ADAM9 Proteins
ADAM9 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP618774HU CSB-EP618774HU CSB-BP618774HU CSB-EP618774HU-B |
Recombinant Human Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP618774HU | Recombinant Human Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9),Partial (Active) | Mammalian cell |
| CSB-MP618774HU1 | Recombinant Human Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9), Partial | Mammalian cell |
ADAM9 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP730719MO CSB-EP730719MO CSB-BP730719MO CSB-EP730719MO-B |
Recombinant Mouse Disintegrin and metalloproteinase domain-containing protein 9 (Adam9), partial | Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli |
ADAM9 ELISA Kit
ADAM9 ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-E11904h | Human A Disintegrin And Metalloprotease 9,ADAM9 ELISA Kit | 15.6 pg/mL |
