ACKR1
ACKR1，即非典型趨化因子受體1，別名FY、Dfy、GPD、DARC、GpFy、CCBP1、CD234、WBCQ1、DARC/ACKR1等。ACKR1由人類ACKR1基因編碼，該基因位于1號(hào)染色體的1q23.2區(qū)域。ACKR1主要通過(guò)結(jié)合、內(nèi)化和降解趨化因子來(lái)調(diào)節(jié)免疫反應(yīng)，作為一種“沉默”的清除受體，它不通過(guò)G蛋白發(fā)出信號(hào)，而是通過(guò)捕獲趨化因子來(lái)調(diào)節(jié)其在循環(huán)中的生物可用性，防止過(guò)度的循環(huán)趨化因子濃度和系統(tǒng)性白細(xì)胞激活，同時(shí)也為趨化因子提供血液儲(chǔ)備（緩沖），延長(zhǎng)其半衰期。ACKR1在調(diào)節(jié)炎癥反應(yīng)和白細(xì)胞遷移中起著重要作用，其表達(dá)的缺失或變異與特定人群對(duì)瘧疾的抵抗力有關(guān)，也與某些血液疾病相關(guān)。
熱銷產(chǎn)品
Recombinant Human Atypical chemokine receptor 1 (ACKR1) (Active) (CSB-CF624105HU)
驗(yàn)證數(shù)據(jù)
Activity
Measured by its binding ability in a functional ELISA. Immobilized ACKR1 at 1 μg/ml can bind human CCL2, the EC50 of human CCL2 protein is 48.64-60.24 μg/ml.
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
DARC Recombinant Monoclonal Antibody (CSB-RA287686A0HU)
驗(yàn)證數(shù)據(jù)
Overlay Peak curve showing 293 cells stained with CSB-RA287686A0HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
ACKR1 Antibodies
ACKR1 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA006504GA01HU | ACKR1 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA008513 | ACKR1 Antibody | Human | IF, ELISA |
| CSB-PA624105LA01HU | ACKR1 Antibody | Human, Mouse | ELISA, WB, IF |
| CSB-RA287686A0HU | DARC Recombinant Monoclonal Antibody | Human | ELISA, FC |
ACKR1 Proteins
ACKR1 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP624105HU1 CSB-EP624105HU1 CSB-BP624105HU1 CSB-MP624105HU1 CSB-EP624105HU1-B |
Recombinant Human Duffy antigen/chemokine receptor (DARC), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF624105HU | Recombinant Human Atypical chemokine receptor 1 (ACKR1) (Active) | in vitro E.coli expression system |
| CSB-MP624105HU | Recombinant Human Atypical chemokine receptor 1 (ACKR1)-VLPs | Mammalian cell |
ACKR1 Proteins for Bos indicus (Zebu)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP769670BUL1 CSB-EP769670BUL1 CSB-BP769670BUL1 CSB-MP769670BUL1 CSB-EP769670BUL1-B |
Recombinant Bos indicus Duffy antigen/chemokine receptor (DARC), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF769670BUL | Recombinant Bos indicus Duffy antigen/chemokine receptor (DARC) | in vitro E.coli expression system |
ACKR1 Proteins for Papio hamadryas (Hamadryas baboon)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP822099ERJ1 CSB-EP822099ERJ1 CSB-BP822099ERJ1 CSB-MP822099ERJ1 CSB-EP822099ERJ1-B |
Recombinant Papio hamadryas Duffy antigen/chemokine receptor (DARC), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF822099ERJ | Recombinant Papio hamadryas Duffy antigen/chemokine receptor (DARC) | in vitro E.coli expression system |
ACKR1 Proteins for Saguinus imperator (Emperor tamarin)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP836101SVX1 CSB-EP836101SVX1 CSB-BP836101SVX1 CSB-MP836101SVX1 CSB-EP836101SVX1-B |
Recombinant Saguinus imperator Duffy antigen/chemokine receptor (DARC), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF836101SVX | Recombinant Saguinus imperator Duffy antigen/chemokine receptor (DARC) | in vitro E.coli expression system |
ACKR1 Proteins for Cebus apella (Brown-capped capuchin)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP839207DQU1 CSB-EP839207DQU1 CSB-BP839207DQU1 CSB-MP839207DQU1 CSB-EP839207DQU1-B |
Recombinant Cebus apella Duffy antigen/chemokine receptor (DARC), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF839207DQU | Recombinant Cebus apella Duffy antigen/chemokine receptor (DARC) | in vitro E.coli expression system |
ACKR1 Proteins for Pan troglodytes (Chimpanzee)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP842558EQV1 CSB-EP842558EQV1 CSB-BP842558EQV1 CSB-MP842558EQV1 CSB-EP842558EQV1-B |
Recombinant Pan troglodytes Duffy antigen/chemokine receptor (DARC), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF842558EQV | Recombinant Pan troglodytes Duffy antigen/chemokine receptor (DARC) | in vitro E.coli expression system |
ACKR1 Proteins for Gorilla gorilla gorilla (Lowland gorilla)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP846503GGZ1 CSB-EP846503GGZ1 CSB-BP846503GGZ1 CSB-MP846503GGZ1 CSB-EP846503GGZ1-B |
Recombinant Gorilla gorilla gorilla Duffy antigen/chemokine receptor (DARC), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF846503GGZ | Recombinant Gorilla gorilla gorilla Duffy antigen/chemokine receptor (DARC) | in vitro E.coli expression system |
ACKR1 Proteins for Macaca mulatta (Rhesus macaque)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP853305MOW1 CSB-EP853305MOW1 CSB-BP853305MOW1 CSB-MP853305MOW1 CSB-EP853305MOW1-B |
Recombinant Macaca mulatta Duffy antigen/chemokine receptor (DARC), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF853305MOW | Recombinant Macaca mulatta Duffy antigen/chemokine receptor (DARC) | in vitro E.coli expression system |
ACKR1 Proteins for Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP856816SWC1 CSB-EP856816SWC1 CSB-BP856816SWC1 CSB-MP856816SWC1 CSB-EP856816SWC1-B |
Recombinant Saimiri boliviensis boliviensis Duffy antigen/chemokine receptor (DARC), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF856816SWC | Recombinant Saimiri boliviensis boliviensis Duffy antigen/chemokine receptor (DARC) | in vitro E.coli expression system |
ACKR1 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP884401BO1 CSB-EP884401BO1 CSB-BP884401BO1 CSB-MP884401BO1 CSB-EP884401BO1-B |
Recombinant Bovine Duffy antigen/chemokine receptor (DARC), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF884401BO | Recombinant Bovine Duffy antigen/chemokine receptor (DARC) | in vitro E.coli expression system |
ACKR1 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP889540MO1 CSB-EP889540MO1 CSB-BP889540MO1 CSB-MP889540MO1 CSB-EP889540MO1-B |
Recombinant Mouse Duffy antigen/chemokine receptor (Darc), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF889540MO | Recombinant Mouse Duffy antigen/chemokine receptor (Darc) | in vitro E.coli expression system |
