PDE5A
PDE5A，即磷酸二酯酶5A，別名cGMP-binding cGMP-specific phosphodiesterase、CGB-PDE。它是磷酸二酯酶家族中的一員，主要在心血管系統(tǒng)和中樞神經(jīng)系統(tǒng)中發(fā)揮作用。它通過水解cGMP（環(huán)磷酸鳥苷）和cAMP（環(huán)磷酸腺苷），調(diào)節(jié)細(xì)胞內(nèi)信號傳導(dǎo)，影響血管舒張、血小板功能和神經(jīng)傳遞。PDE5A的活性與多種疾病相關(guān)，包括心血管疾病、性功能障礙和某些類型的癌癥。PDE5A抑制劑，如西地那非，被用于治療勃起功能障礙和肺動脈高壓，同時，它們還可能在神經(jīng)保護(hù)和抗癌領(lǐng)域發(fā)揮作用。因此，PDE5A是藥物開發(fā)和疾病治療中的一個關(guān)鍵靶點(diǎn)。
熱銷產(chǎn)品
Recombinant Human cGMP-specific 3',5'-cyclic phosphodiesterase (PDE5A) , partial (CSB-YP524921HU)
驗證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
驗證數(shù)據(jù)
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA126186(PDE5A Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA126186(PDE5A Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: 293T cells, Primary antibody: CSB-PA126186(PDE5A Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
PDE5A Antibodies
PDE5A for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA126186 | PDE5A Antibody | Human | ELISA,WB,IHC |
| CSB-PA132496 | PDE5A Antibody | Human | ELISA,IHC |
PDE5A Proteins
PDE5A Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP523851RA CSB-EP523851RA CSB-BP523851RA CSB-MP523851RA CSB-EP523851RA-B |
Recombinant Rat cGMP-specific 3',5'-cyclic phosphodiesterase (Pde5a), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PDE5A Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-EP524921HU CSB-BP524921HU CSB-MP524921HU CSB-EP524921HU-B |
Recombinant Human cGMP-specific 3',5'-cyclic phosphodiesterase (PDE5A), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP524921HU | Recombinant Human cGMP-specific 3',5'-cyclic phosphodiesterase (PDE5A) , partial | Yeast |
PDE5A Proteins for Canis familiaris (Dog) (Canis lupus familiaris)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP529249DO CSB-EP529249DO CSB-BP529249DO CSB-MP529249DO CSB-EP529249DO-B |
Recombinant Dog cGMP-specific 3',5'-cyclic phosphodiesterase (PDE5A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PDE5A Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP634661BO CSB-EP634661BO CSB-BP634661BO CSB-MP634661BO CSB-EP634661BO-B |
Recombinant Bovine cGMP-specific 3',5'-cyclic phosphodiesterase (PDE5A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PDE5A Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP807017MO CSB-BP807017MO CSB-MP807017MO CSB-EP807017MO-B |
Recombinant Mouse cGMP-specific 3',5'-cyclic phosphodiesterase (Pde5a), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP807017MO | Recombinant Mouse cGMP-specific 3,5-cyclic phosphodiesterase (Pde5a), partial | E.coli |
