NFE2L2

NFE2L2，即核因子（紅細(xì)胞衍生2）相關(guān)因子2，別名NRF2、NFE2L2。它是一種轉(zhuǎn)錄因子，由人體細(xì)胞自身的基因編碼，在細(xì)胞防御氧化應(yīng)激和清除有害物質(zhì)中發(fā)揮關(guān)鍵作用。NFE2L2的作用機(jī)制涉及多個(gè)層面，包括翻譯后修飾、蛋白相互作用和表觀遺傳調(diào)控等。在正常生理?xiàng)l件下，NFE2L2與KEAP1結(jié)合并通過(guò)泛素-蛋白酶體途徑促進(jìn)其降解，維持NFE2L2表達(dá)在較低水平。當(dāng)細(xì)胞遭遇氧化應(yīng)激或親電試劑時(shí)，NFE2L2會(huì)從細(xì)胞質(zhì)轉(zhuǎn)移到細(xì)胞核，與抗氧化反應(yīng)元件(ARE)結(jié)合，激活抗氧化相關(guān)基因的轉(zhuǎn)錄。NFE2L2在生物學(xué)上的意義非常廣泛，它參與調(diào)控黃曲霉毒素分解代謝過(guò)程、大分子代謝過(guò)程的正向調(diào)控以及細(xì)胞遷移的調(diào)節(jié)。NFE2L2的功能異常與多種疾病相關(guān)，包括糖尿病視網(wǎng)膜病變、肝硬化、大腦中動(dòng)脈梗塞、非酒精性脂肪肝病等。此外，NFE2L2的人類(lèi)直系同源基因與阿爾茨海默病、白內(nèi)障、肝細(xì)胞癌、黃斑變性、肺結(jié)核等疾病有關(guān)。在癌癥中，NFE2L2-KEAP1信號(hào)通路經(jīng)常被劫持，尤其是在非小細(xì)胞肺癌中，NFE2L2的激活可導(dǎo)致癌細(xì)胞逃脫各種抗腫瘤治療，促進(jìn)疾病進(jìn)展和轉(zhuǎn)移。因此，NFE2L2是細(xì)胞氧化應(yīng)激反應(yīng)和疾病治療中的一個(gè)重要靶點(diǎn)。

熱銷(xiāo)產(chǎn)品

Recombinant Human Nuclear factor erythroid 2-related factor 2 (NFE2L2), partial (CSB-EP614961HU1)

驗(yàn)證數(shù)據(jù)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

NFE2L2 Recombinant Monoclonal Antibody (CSB-RA225569A0HU)

驗(yàn)證數(shù)據(jù)

Immunofluorescence staining of Hela Cells with CSB-RA225569A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).

NFE2L2 Antibody

NFE2L2 Protein

NFE2L2 ELISA Kit

NFE2L2 Antibodies

NFE2L2 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	種屬反應(yīng)性	應(yīng)用類(lèi)型
CSB-PA009136GA01HU	NFE2L2 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA828758	NFE2L2 Antibody	Human,Mouse,Rat	ELISA,WB,IHC,IF
CSB-PA000152	Acetyl-NFE2L2 (K599) Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA003481	NFE2L2 Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA005517	NFE2L2 Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA080280	NFE2L2 Antibody	Human,Mouse,Rat	WB, IHC
CSB-PA777170	NFE2L2 Antibody	Human,Mouse,Rat	IHC,ELISA
CSB-RA614961A40phHU	Phospho-NFE2L2 (S40) Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, IF
CSB-PA614961LA01HU	NFE2L2 Antibody	Human	ELISA, IF
CSB-PA614961LB01HU	NFE2L2 Antibody, HRP conjugated	Human	ELISA
CSB-PA614961LC01HU	NFE2L2 Antibody, FITC conjugated	Human
CSB-PA614961LD01HU	NFE2L2 Antibody, Biotin conjugated	Human	ELISA
CSB-RA225569A0HU	NFE2L2 Recombinant Monoclonal Antibody	Human	ELISA, IF
CSB-MA614961A0m	NFE2L2 Monoclonal Antibody	Human, Mouse	ELISA, WB, IHC, IF, FC

NFE2L2 Proteins

NFE2L2 Proteins for Rattus norvegicus (Rat)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP015752RA CSB-EP015752RA CSB-BP015752RA CSB-MP015752RA CSB-EP015752RA-B	Recombinant Rat Nuclear factor erythroid 2-related factor 2 (Nfe2l2)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

NFE2L2 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP614961HU CSB-BP614961HU CSB-MP614961HU CSB-EP614961HU-B	Recombinant Human Nuclear factor erythroid 2-related factor 2 (NFE2L2)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP614961HU	Recombinant Human Nuclear factor erythroid 2-related factor 2 (NFE2L2)	E.coli
CSB-EP614961HU1	Recombinant Human Nuclear factor erythroid 2-related factor 2 (NFE2L2), partial	E.coli

NFE2L2 Proteins for Bos taurus (Bovine)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP708916BO CSB-EP708916BO CSB-BP708916BO CSB-MP708916BO CSB-EP708916BO-B	Recombinant Bovine Nuclear factor erythroid 2-related factor 2 (NFE2L2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

NFE2L2 Proteins for Mus musculus (Mouse)

產(chǎn)品貨號(hào)	產(chǎn)品名稱(chēng)	來(lái)源
CSB-YP726674MO CSB-BP726674MO CSB-MP726674MO CSB-EP726674MO-B	Recombinant Mouse Nuclear factor erythroid 2-related factor 2 (Nfe2l2)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli