CSF3R
CSF3R全稱為集落刺激因子3受體，又稱粒細(xì)胞集落刺激因子受體（G-CSFR），屬于I型細(xì)胞因子受體超家族。CSF3R由胞外配體結(jié)合區(qū)、跨膜結(jié)構(gòu)域及胞內(nèi)信號(hào)傳導(dǎo)域組成，主要通過(guò)與粒細(xì)胞集落刺激因子（G-CSF）結(jié)合，調(diào)控中性粒細(xì)胞的增殖、分化及存活。在血液系統(tǒng)疾病中，CSF3R基因突變與先天性中性粒細(xì)胞減少癥、慢性中性粒細(xì)胞白血病密切相關(guān)，特別是截短型突變可導(dǎo)致受體持續(xù)激活，引發(fā)髓系腫瘤。近年來(lái)研究發(fā)現(xiàn)，約30%的慢性中性粒細(xì)胞白血病患者攜帶該基因突變，成為診斷分型的重要標(biāo)志。針對(duì)CSF3R信號(hào)異常，JAK抑制劑魯索替尼已用于攜帶CSF3R-T618I突變患者的臨床治療，而重組G-CSF制劑如培非格司亭則廣泛用于化療后粒細(xì)胞缺乏的挽救治療。目前針對(duì)該靶點(diǎn)的單克隆抗體藥物及小分子激酶抑制劑已進(jìn)入臨床試驗(yàn)階段，為髓系腫瘤精準(zhǔn)治療提供新方向。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CSF3R Recombinant Monoclonal Antibody (CSB-RA860321MA1HU)
驗(yàn)證數(shù)據(jù)
IHC image of CSB-RA860321MA1HU diluted at 1：100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.
IHC image of CSB-RA860321MA1HU diluted at 1：100 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.
CSF3R Antibodies
CSF3R for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA004693 | CSF3R Antibody | Human | WB, ELISA |
| CSB-PA006057 | CSF3R Antibody | Human | WB, ELISA |
| CSB-PA300322 | CSF3R Antibody | Human | ELISA,IHC |
| CSB-PA094529 | CSF3R Antibody | Human | ELISA,IHC |
| CSB-PA860321LA01HU | CSF3R Antibody | Human | ELISA, IHC, IF |
| CSB-PA860321LB01HU | CSF3R Antibody, HRP conjugated | Human | ELISA |
| CSB-PA860321LC01HU | CSF3R Antibody, FITC conjugated | Human | |
| CSB-PA860321LD01HU | CSF3R Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA860321MA1HU | CSF3R Recombinant Monoclonal Antibody | Human | ELISA, IHC |
CSF3R Proteins
CSF3R Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-YP006050MO CSB-EP006050MO CSB-BP006050MO CSB-MP006050MO CSB-EP006050MO-B |
Recombinant Mouse Granulocyte colony-stimulating factor receptor (Csf3r), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSF3R Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來(lái)源 |
|---|---|---|
| CSB-EP860321HU1 | Recombinant Human Granulocyte colony-stimulating factor receptor (CSF3R), partial | E.coli |
| CSB-YP860321HU CSB-EP860321HU CSB-BP860321HU CSB-MP860321HU CSB-EP860321HU-B |
Recombinant Human Granulocyte colony-stimulating factor receptor (CSF3R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP860321HU2 | Recombinant Human Granulocyte colony-stimulating factor receptor (CSF3R), partial | E.coli |
| CSB-MP860321HUi10 | Recombinant Human Granulocyte colony-stimulating factor receptor (CSF3R), partial | Mammalian cell |
