CASP6
胱天蛋白酶6（CASP6）是一種參與細(xì)胞凋亡的蛋白酶，在神經(jīng)退行性疾病的發(fā)生發(fā)展中發(fā)揮重要作用。CASP6 的全稱是胱天蛋白酶6，常見別名包括 MCH2、CASP 6 等。CASP6 通過切割多種底物，如聚（ADP-核糖）聚合物、層蛋白等，參與細(xì)胞凋亡的執(zhí)行階段。研究表明，CASP6 在亨廷頓舞蹈癥和阿爾茨海默病的細(xì)胞凋亡、早期免疫反應(yīng)和神經(jīng)變性中發(fā)揮重要作用。CASP6 的異常激活與神經(jīng)退行性疾病的神經(jīng)元過度死亡有關(guān)，因此成為治療這些疾病的重要靶點(diǎn)。目前，針對 CASP6 的藥物研發(fā)正在積極進(jìn)行中，包括開發(fā) CASP6 抑制劑等，以期通過抑制 CASP6 的活性，減少神經(jīng)炎癥和神經(jīng)元死亡，從而治療神經(jīng)退行性疾病。
熱銷產(chǎn)品
CASP6 Recombinant Monoclonal Antibody (CSB-RA065800A0HU)
驗證數(shù)據(jù)
Western Blot
Positive WB detected in: K562 whole cell lysate(30μg)
All lanes: Caspase 6 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/40000 dilution
Predicted band size: 34 kDa
Observed band size: 34 kDa
Exposure time：2min
Immunofluorescence staining of PC-3 cell with CSB-RA065800A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Overlay Peak curve showing jurkat cells stained with CSB-RA065800A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
CASP6 Antibodies
CASP6 for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA004551GA01HU | CASP6 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA004551ESR2HU | CASP6 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-PA004551ESR1HU | CASP6 Antibody | Human | ELISA, WB, IHC |
| CSB-PA000006 | Cleaved-CASP6 (D179) Antibody | Human,Rat | WB, IHC, ELISA |
| CSB-PA000084 | CASP6 Antibody | Human | WB, ELISA |
| CSB-PA001232 | CASP6 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA060289 | Phospho-CASP6 (S257) Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
| CSB-PA143409 | CASP6 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA098112 | CASP6 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA004551EA01HU | CASP6 Antibody | Human, Mouse | ELISA, WB, IHC |
| CSB-RA065800A0HU | CASP6 Recombinant Monoclonal Antibody | Human | ELISA, WB, IF, FC |
CASP6 for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA000005 | Cleaved-CASP6 (D162) Antibody | Mouse,Rat | WB, IHC, ELISA |
CASP6 Proteins
CASP6 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004551HU CSB-EP004551HU CSB-BP004551HU CSB-MP004551HU CSB-EP004551HU-B |
Recombinant Human Caspase-6 (CASP6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CASP6 Proteins for Mus musculus (Mouse)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004551MO CSB-EP004551MO CSB-BP004551MO CSB-MP004551MO CSB-EP004551MO-B |
Recombinant Mouse Caspase-6 (Casp6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CASP6 Proteins for Rattus norvegicus (Rat)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP004551RA CSB-EP004551RA CSB-BP004551RA CSB-MP004551RA CSB-EP004551RA-B |
Recombinant Rat Caspase-6 (Casp6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CASP6 Proteins for Bos taurus (Bovine)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP667517BO CSB-EP667517BO CSB-BP667517BO CSB-MP667517BO CSB-EP667517BO-B |
Recombinant Bovine Caspase-6 (CASP6) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
