Recombinant Rat SMR1 protein (Vcsa1)

中文名稱：

大鼠Vcsa1重組蛋白
貨號：

CSB-YP320225RA
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

大鼠Vcsa1重組蛋白
貨號：

CSB-EP320225RA
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

大鼠Vcsa1重組蛋白
貨號：

CSB-EP320225RA-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

大鼠Vcsa1重組蛋白
貨號：

CSB-BP320225RA
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

大鼠Vcsa1重組蛋白
貨號：

CSB-MP320225RA
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

Vcsa1
Uniprot No.：

P13432
別名：

Vcsa1; Smr1; SMR1 protein; VCS-alpha 1) [Cleaved into: SMR1-related undecapeptide; SMR1-related hexapeptide; Sialorphin; SMR1-related pentapeptide); Submandibular gland peptide T; SGP-T)]
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full Length of Mature Protein
表達區域：

23-146
氨基酸序列

VRGPRRQH NPRRQQDPST LPHYLGLQPD PNGGQIGVTI TIPLNLQPPR VLVNLPGFIT GPPLVVQGTT EYQYQWQLTA PDPTPLSNPP TQLHSTEQAN TKTDAKISNT TATTQNSTDI FEGGGK
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Sialorphin may be involved in the modulation of mineral balance between at least four systems: kidney, bone, tooth and circulation.; Submandibular gland peptide T is able to directly or indirectly down-regulate cardiovascular depression induced by septic shock (endotoxin stimuli), or anaphylactic challenge (nematode antigen sensitization).; Sialorphin is an endogenous inhibitor of neprilysin. Inhibits the breakdown of Met-enkephalin and substance P in isolated tissue from the dorsal zone of the rat spinal cord. Has an analgesic effect when administered to rats by intravenous injection.
基因功能參考文獻：
1. When rat corporal smooth muscle cells were treated with CoCl2 or low oxygen tension to mimic hypoxia, Vcsa1 was increased tenfold. PMID: 24803544
2. Sialorphin protects endogenous enkephalins released after nociceptive stimuli by inhibiting neprilysin in vivo. It is a natural systemically active regulator of NEP activity & is a physiological modulator of pain perception after injury PMID: 12835417
3. Sialorphin increased, in a dose-related manner, the occurrence of intromissions across the successive ejaculatory sequences. PMID: 15555512
4. Autonomic nervous system regulates secretion of anti-inflammatory prohormone SMR1 from rat salivary glands. PMID: 19109528
5. correlation of erectile function, testosterone levels and Vcsa1 expression in orchiectomized rats and controls PMID: 19428993
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亞細胞定位：

Secreted. Note=Found in blood. Secreted from the salivary compartment into the blood circulation, rather than through absorption by the gastro-intestinal tract.
組織特異性：

Expressed predominantly in the acinar cells of the submandibular gland and to lesser extent in the prostate.
數據庫鏈接：

KEGG: rno:24867

STRING: 10116.ENSRNOP00000035658

UniGene: Rn.169239