Recombinant Rat T-cell-specific surface glycoprotein CD28 (Cd28)

in vitro E.coli expression system

中文名稱：

Recombinant Rat T-cell-specific surface glycoprotein CD28(Cd28)
貨號：

CSB-CF004913RA
說明書：

MSDS Datasheet
規(guī)格：
來源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

基因名：

Cd28
Uniprot No.：

P31042
別名：

Cd28; T-cell-specific surface glycoprotein CD28; CD antigen CD28
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full Length of Mature Protein
表達區(qū)域：

20-218
氨基酸序列

NKILVKQSPLLVVDNNEVSLSCRYSYNLLAKEFRASLYKGVNSDVEVCVGNGNFTYQPQFRPNVGFNCDGNFDNETVTFRLWNLDVNHTDIYFCKIEVMYPPPYLDNEKSNGTIIHIKEKHLCHAQTSPKLFWPLVVVAGVLLCYGLLVTVTLCIIWTNSRRNRLLQSDYMNMTPRRLGPTRKHYQPYAPARDFAAYRP
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation.
基因功能參考文獻：
1. this study identified two crucial immune-related molecules-CD28 and NFATc1, as putative targets of miR-145 in human and experimental myasthenia gravis PMID: 24043548
2. CD28 superagonist antibody treatment attenuated obliterative bronchiolitis in rat allo-orthotopic tracheal transplantation by preferentially expanding Foxp3-expressing regulatory T cells. PMID: 22564625
3. Data demonstrate that the superagonistic monoclonal antibody for CD28, JJ316, preferentially expanded Treg cells. PMID: 21487638
4. Data show several homologies across human, rat and mouse in the kinetic of loss of several LAgs such as CD5, CD4 and CD28. PMID: 21745657
5. Tongbi Mixture 2 can inhibit T lymphocytes through down-regulating the expressions of CD28 and CD152. PMID: 18601859
6. the Th2-response in mercuric chloride-induced autoimmunity requires continuing costimulation via CD28 PMID: 12197880
7. Data show that superagonists bind to the laterally exposed C"D loop of the immunoglobulin-like domain of CD28 but conventional, costimulatory monoclonal antibodies recognize an epitope close to the binding site for the natural CD80/CD86 ligands. PMID: 12707299
8. translocation to lipid rafts may play an important role in CD28 signaling. PMID: 15280538
9. Mechanism for lack of Cbl-b down-regulation may involve the proteasome since blocking proteasomal activity in young T-lymphocytes prevented Cbl-b down regulation while there was no effect in aged T-lymphocytes on Cbl-b expression. PMID: 15491677
10. CD28 negative T suppressor cells protect allogenic recipients from acute rejection in rats liver transplantation. PMID: 18089392
11. CD28 superagonists elicit 2 qualitatively distinct waves of activation PMID: 18357346
12. Targeting the CD28 antigen with a blocking antibody leads to long-term allograft survival by reducing activation of alloantigen-mediated key signaling events in T cells that might be crucial for full T cell activation. PMID: 18408588
13. CD28 antibody induces donor-specific tolerance in rat renal allografts PMID: 18727698
14. CD2/CD28 costimulation is the strongest T cell stimulus in vivo in rat lamina propria. PMID: 19811406
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亞細胞定位：

Membrane; Single-pass type I membrane protein.
數(shù)據(jù)庫鏈接：

KEGG: rno:25660

STRING: 10116.ENSRNOP00000013701

UniGene: Rn.10327