Recombinant Rat Small conductance calcium-activated potassium channel protein 1 (Kcnn1)

in vitro E.coli expression system

中文名稱：

大鼠Kcnn1重組蛋白
貨號：

CSB-CF012083RA
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

Kcnn1
Uniprot No.：

P70606
別名：

Kcnn1; Sk1; Small conductance calcium-activated potassium channel protein 1; SK1; SKCa 1; SKCa1; KCa2.1
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full length protein
表達區域：

1-536
氨基酸序列

MSSRSHNGSVGRPLGSGPGFLGWEPVDPEAGRPRQPTQGPGLQMMAKGQPAGLSPSGPRGHSQAQEEEEEEEDEDRPGSGKPPTVSHRLGHRRALFEKRKRLSDYALIFGMFGIVVMVTETELSWGVYTKESLCSFALKCLISLSTVILLGLVILYHAREIQLFLVDNGADDWRIAMTWERVSLISLELAVCAIHPVPGHYRFTWTARLAFSLVPSAAEADVDVLLSIPMFLRLYLLARVMLLHSRIFTDASSRSIGALNRVTFNTRFVTKTLMTICPGTVLLVFSISSWIVAAWTVRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQSRVRKHQRKFLQAIHQAQKLRTVKIEQGKVNDQANTLADLAKAQSIAYEVVSELQAQQEELEARLAALESRLDVLGASLQALPSLIAQAICPLPPPWPGPSHLTTAAQSPQSHWLPTTASDCG
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 668
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization.
基因功能參考文獻：
1. SK channel current is a substantial element in sustaining the substantia nigra pars compacta dopaminergic neuroal rhythmic pacemaking. PMID: 24841382
2. This study demonistrated that SK1 and SK2 transcripts showed strong expression starting from E15 in the striatum and decreased throughout pre- and postnatal development. PMID: 24096910
3. Small conductance Ca(2+)-activated K(+) (SK) channels expressed in the hypothalamic paraventricular nucleus play an important role in the regulation of sympathetic outflow and cardiovascular function. PMID: 22647293
4. expressed in myometrium throughout pregnancy and contribute to outward current, regulate membrane potential and calcium signalling PMID: 19969350
5. rSK1 subunit is synthesized in cells but does not form functional homomeric channels PMID: 14761961
6. These results implicate SK1 subunits as key regulators of excitability and endocrine function in beta cells. PMID: 19101546
7. downregulation of SK1 and SK3 channels and upregulation of SK2 channels provide direct evidence that these Ca2+-activated K+ channels play important roles in inferior colliculi neuronal hyperexcitability that leads to inherited seizure susceptibility PMID: 19254702
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亞細胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

Potassium channel KCNN family, KCa2.1/KCNN1 subfamily
組織特異性：

Widely expressed including brain.
數據庫鏈接：

KEGG: rno:54261

STRING: 10116.ENSRNOP00000042517

UniGene: Rn.44422