Recombinant Rat Membrane-associated progesterone receptor component 1 (Pgrmc1)

in vitro E.coli expression system

中文名稱：

大鼠Pgrmc1重組蛋白
貨號：

CSB-CF017876RA
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

Pgrmc1
Uniprot No.：

P70580
別名：

Pgrmc1; 25dx; Lewi; Pgrmc; Membrane-associated progesterone receptor component 1; mPR; 25-DX; Acidic 25 kDa protein; Ventral midline antigen; VEMA
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full Length of Mature Protein
表達區域：

2-195
氨基酸序列

AAEDVVATGADPSELEGGGLLQEIFTSPLNLLLLGLCIFLLYKIVRGDQPGASGDNDDDEPPPLPRLKPRDFTPAELRRYDGVQDPRILMAINGKVFDVTKGRKFYGPEGPYGVFAGRDASRGLATFCLDKEALKDEYDDLSDLTPAQQETLNDWDSQFTFKYHHVGKLLKEGEEPTVYSDDEEPKDEAARKSD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins. May be implicated in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) immunotoxicity.
基因功能參考文獻：
1. The PGRMC1 expression level correlates with the binding activity of SW120 in rat brain cells. PMID: 26335282
2. PGRMC1 and PGRMC2 are involved in regulating entry into the G1 stage of the cell cycle. PMID: 25253729
3. Knockdown by siRNA-Pgrmc1 in microglia before add-back to astrocyte-neuron cocultures suppressed the P4-E2 antagonism of neurite outgrowth PMID: 23653459
4. After brain injury, mPRalpha expression was induced in oligodendrocytes, astrocytes and reactive microglia. This points to a role in mediating modulatory effects of progesterone in inflammation, ion and water homeostasis and myelin repair in the injured brain PMID: 23211561
5. The ability to suppress Tcf/Lef activity is part of the mechanism through which P4 activation of PGRMC1 regulates the gene cascades that control granulosa cell function with this action being dependent in part on the sumoylation status of PGRMC1. PMID: 22719051
6. Pgrmc1 and Pgrmc2 may play roles in neuroendocrine and reproductive functions of the female rat. PMID: 20977928
7. PGRMC1 protein complex identified as the putative sigma-2 receptor binding site. PMID: 21730960
8. roles of progesterone (P4) and Progesterone Receptor Membrane Component 1 (PGRMC1) in regulating mitosis of spontaneously immortalized granulosa cells (SIGCs). P4's actions appear to be dependent on PGRMC1's function within the mitotic spindle. PMID: 21148105
9. The present studies suggest a genomic component to PGRMC1's anti-apoptotic mechanism of action, which requires the presence of the PGRMC1 dimer. PMID: 20144686
10. Membrane-bound progesterone receptor (mPR) is a mediator of physiologic effects of the sex hormones. PMID: 15570619
11. Expression of 25-Dx in structures involved in CSF production and in osmoregulation, and its up-regulation after brain damage, point to role of this progesterone-binding protein in maintenance of water homeostasis after traumatic brain injury. PMID: 15934950
12. Molecular identification of 25-Dx had it as a heme-binding protein. PMID: 16279947
13. PGRMC1 is the progesterone binding protein that mediates P4's antiapoptotic action PMID: 17991724
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亞細胞定位：

Microsome membrane; Single-pass membrane protein. Smooth endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein; Extracellular side.
蛋白家族：

Cytochrome b5 family, MAPR subfamily
組織特異性：

Expressed at high levels in lung, liver, kidney and brain, low in testis and spleen. Not expressed in heart and skeletal muscle.
數據庫鏈接：

KEGG: rno:291948

STRING: 10116.ENSRNOP00000017101

UniGene: Rn.102356