Recombinant Rat Leukotriene C4 synthase (Ltc4s)

in vitro E.coli expression system

中文名稱：

大鼠Ltc4s重組蛋白
貨號：

CSB-CF013228RA
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

Ltc4s
Uniprot No.：

Q925U2
別名：

Ltc4s; Leukotriene C4 synthase; LTC4 synthase; Glutathione S-transferase LTC4; Leukotriene-C(4 synthase
種屬：

Rattus norvegicus (Rat)
蛋白長度：

full length protein
表達區域：

1-150
氨基酸序列

MKEETALLATVTLVGVLLQAYFSLQVISARRTFHVSPPLTSGPPEFERVFRAQVNCSEYF PLFLATLWVAGIFFHEGAAALCGLFYLFARLRYFQGYARSAQHRLDPLYASARALWLLVA MAALGLLVHFLPGTLRAALFRWLQVLLPMA
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity. Can also catalyzes the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions.
基因功能參考文獻：
1. LTC4S and Orai3 altered Akt signaling to promote VSMC migration and neointima formation. PMID: 25540197
2. 5-LOX is involved in global cerebral ischemic damage in rats PMID: 23505109
3. molecular cloning; elevated expression in rat basophilic leukemia-1 cells after treatment with retinoic acid PMID: 12445492
4. Induction in basophilic leukemia cells with retinoice acid and actinomycin D; suppressed with methylprednisolone. PMID: 12767051
5. LTC4S may be involved in acute systemic inflammatory responses such as fever and tachycardia. PMID: 15619010
6. BRET data showed that hydrophobic regions 1 and 3 each allowed oligomerization to occur. These regions most likely form transmembrane helices, suggesting that homo-oligomerization of LTC4S is due to helix-helix interactions in the membrane. PMID: 16552728
7. hepatic ischemia reperfusion injury up-regulated the mRNA and protein expressions of LTC4S in hepatocytes and sinusoidal endothelial cells and enhanced the activities of the LTC4 synthesis enzymes PMID: 17397868
8. In the myeloid cells, but not in the epithelial cells, we observed that the leukotriene C(4) synthase promoter activity was stimulated by 12-O-tetradecanoylphorbol-13-acetate and all-trans-retinoic acid. PMID: 18053799
9. Liver LTC4S was up-regulated in rat model of fulminant hepatic failure. PMID: 18461660
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亞細胞定位：

Nucleus outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein.
蛋白家族：

MAPEG family
數據庫鏈接：

KEGG: rno:114097

STRING: 10116.ENSRNOP00000004359

UniGene: Rn.38594