Recombinant Rat Gonadotropin-releasing hormone receptor (Gnrhr)

in vitro E.coli expression system

中文名稱：

大鼠Gnrhr重組蛋白
貨號(hào)：

CSB-CF009637RA
說(shuō)明書：

MSDS Datasheet
規(guī)格：
來(lái)源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

基因名：

Gnrhr
Uniprot No.：

P30969
別名：

Gnrhr; Gonadotropin-releasing hormone receptor; GnRH receptor; GnRH-R
種屬：

Rattus norvegicus (Rat)
蛋白長(zhǎng)度：

Full length protein
表達(dá)區(qū)域：

1-327
氨基酸序列

MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKL QRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYL KLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRM IYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRV LHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVS EPVNHFFFLFAFLNPCFDPLIYGYFSL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system.
基因功能參考文獻(xiàn)：
1. the age-dependent basal and regulated Gnrhr transcription could account for the initial blockade and subsequent activation of the reproductive system during development. PMID: 27569529
2. Prevention of estradiol synthesis blocked the ability of peripheral estradiol administration in ovariectomized rats to enhance hippocampus-dependent memory in a radial-maze task. Hippocampal GnRH receptor antagonism blocked the ability of peripheral estradiol administration in ovariectomized rats to enhance hippocampus-dependent memory. PMID: 28032117
3. GnRH-R is expressed in the mammary tissues after weaning; GnRH is involved in the involution and tissue remodeling of post-lactating rat mammary tissues PMID: 27349532
4. Gnrhr promoter sequences are mainly responsible for directing transcriptional programmes and play a predominant role over the species-specific cell environment. PMID: 25556311
5. Data indicate that GnRH-R expression is strongest in the hippocampus of adult female rats. PMID: 23906992
6. Rather than using alternate promoters, Gnrhr expression is directed to diverse cell lineages through specific associations of transcription factors acting on distinct response elements along the same promoter. PMID: 22414758
7. SET protein interacts with intracellular domains of the gonadotropin-releasing hormone receptor and differentially regulates receptor signaling to cAMP and calcium in gonadotrope cells PMID: 23233674
8. Data demonstrate herein that the onset of GnRHR gene (Gnrhr) expression in the rat hippocampus was unexpectedly delayed as compared to the pituitary and only occurred after birth. PMID: 21123436
9. Low-level GnRHR expression in the ovaries of rats with cyclophosphamide exposure suggest microenvironment disturbances in the damaged rat ovaries in advanced stage of chemotherapy. PMID: 18024297
10. Localization of a functional GHRH-R in Henle's loop and its regulation during development and aging suggest roles associated with cellular proliferation, differentiation, and/or water/electrolyte transport PMID: 11897706
11. Data show that removal of all three carboxyl terminal residues or mutation of the gonadotropin-releasing hormone receptor at Phe(325) caused a complete loss of measurable ligand binding and effector coupling, clearly suggesting a role for Phe(325). PMID: 11997175
12. results indicate that the GnRH receptor activates both G(q) and G(s) signaling to regulate gene expression in L beta T2 cells PMID: 12050161
13. role of the GnRHR carboxyl-terminus in the regulation of the GnRHR by RGS (regulators of G protein signaling) proteins PMID: 12062898
14. The distribution of androgen receptor and its coexistence with gonadotropin releasing hormone receptor in rat submaxillary glands PMID: 12479044
15. GnRH receptor immunoreactive materials were colocalized in the epithelial cells of the serous acinus and glandular duct of the submaxillary gland PMID: 12697272
16. Position of Pro and Ser near Glu7.32 in the extracellular loop 3 is critical for the differential ligand selectivity between mammalian and nonmammalian GnRHRs. PMID: 14525953
17. direct role for the GnRHR in mediating antiproliferative events in two cell systems, neither of which was derived from extrapituitary reproductive tumors. PMID: 14551223
18. Developmental GnRH-R and gonadotropin beta subunit gene expression is almost entirely GnRH dependent, not only in the juvenile prepubertal stage but also during the infantile period. PMID: 14561652
19. GnRH receptor can be expressed by gastric smooth muscle cells of rats. PMID: 15188505
20. the HFRK motif in the membrane-proximal region confers the differential signal transduction pathways between mammalian and nonmammalian GnRHRs PMID: 15563546
21. there are species-specific dominant negative receptor trafficking effects of the GnRHR between human, rat and mouse PMID: 15886197
22. GnRH-R mRNA in the pituitary and hypothalamus of long-term ovariectomized (OVX) rats, at different times of day. PMID: 16672174
23. proportion of the human and the rat WT GnRHR appears to be retained in the endoplasmic reticulum by calnexin, an effect that decreases GnRHR signaling capacity PMID: 17170088
24. These results, for the first time, support the transcription of GnRHR mRNA and its translation to protein in the rat oviduct throughout the postimplantation period of pregnancy. PMID: 17875654
25. Results indicate that the residues flanking Glu(7.32) of the mammalian type-I gonadotropin-releasing hormone receptor are important for antagonist as well as agonist selectivity. PMID: 18319619
26. Both cultured spinal cord neurons of rat embryos and adult rats expressed the GnRH receptor mRNA. GnRH may play other roles independently from its participation in reproductive function. PMID: 19539704
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亞細(xì)胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 1 family
數(shù)據(jù)庫(kù)鏈接：

KEGG: rno:81668

STRING: 10116.ENSRNOP00000002755

UniGene: Rn.112595