Recombinant Rat Beta-3 adrenergic receptor (Adrb3)

in vitro E.coli expression system

中文名稱：

Recombinant Rat Beta-3 adrenergic receptor(Adrb3)
貨號：

CSB-CF001393RA
規(guī)格：
來源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

基因名：

Adrb3
Uniprot No.：

P26255
別名：

Adrb3; Adrb3r; Beta-3 adrenergic receptor; Beta-3 adrenoreceptor; Beta-3 adrenoceptor
種屬：

Rattus norvegicus (Rat)
蛋白長度：

Full length protein
表達區(qū)域：

1-400
氨基酸序列

MAPWPHKNGSLAFWSDAPTLDPSAANTSGLPGVPWAAALAGALLALATVGGNLLVITAIA RTPRLQTITNVFVTSLATADLVVGLLVMPPGATLALTGHWPLGATGCELWTSVDVLCVTA SIETLCALAVDRYLAVTNPLRYGTLVTKRRARAAVVLVWIVSATVSFAPIMSQWWRVGAD AEAQECHSNPRCCSFASNMPYALLSSSVSFYLPLLVMLFVYARVFVVAKRQRRLLRRELG RFPPEESPRSPSRSPSPATVGTPTASDGVPSCGRRPARLLPLGEHRALRTLGLIMGIFSL CWLPFFLANVLRALVGPSLVPSGVFIALNWLGYANSAFNPLIYCRSPDFRDAFRRLLCSY GGRGPEEPRVVTFPASPVASRQNSPLNRFDGYEGERPFPT
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
基因功能參考文獻：
1. In heart failure, the expression of cardiac beta3-adrenergic receptors (beta3-ARs) increases. However, the precise role of beta3-AR signaling within cardiomyocytes remains unclear. The beta3-AR activation in cardiomyocytes increases the expression of TGFbeta1 via the PKG/JNK/c-Jun pathway. PMID: 29859189
2. Study demonstrates that MRI allows a precocious detection of the subtle myocardial dysfunction induced by beta1-adrenoreceptors-autoantibodies (beta1-aabs) and that beta3-adrenoreceptor stimulation blunts the development of beta1-aabs-induced dilated cardiomyopathy. PMID: 28276515
3. Increasing beta3-AR stimulation may prevent the consequences of chronic NA exposure on Na(+)/K(+) pump and in vivo hemodynamics. beta3-AR agonism may thus represent a new therapeutic strategy for pharmacological modulation of hypertrophy under conditions of chronically enhanced sympathetic activity. PMID: 29363058
4. After 16 h of lipopolysaccharide treatment, cultured neonatal cardiomyocytes showed a diminished Ca2+ transient amplitude associated with an increase in the beta3-AR level. PMID: 29566368
5. role of beta2- and beta3-adrenoceptors in arterial stiffness in a state of hypertension PMID: 29208473
6. Inhibition of cholinergic neurotransmission by beta3-adrenoceptors results from adenosine release via equilibrative nucleoside transporters and prejunctional A1-receptor stimulation in urinary bladder. PMID: 28446460
7. The expression of beta3-adrenoceptor and muscarinic type 3 receptor immuno-reactivity in the major pelvic ganglion of the rat. PMID: 25920933
8. sympathetic denervation-induced MSC mobilization in rat mandibular distraction osteogenesis is associated with inhibition of MSC migration and osteogenic differentiation by NE/adrb3 PMID: 25144690
9. It can be concluded that BRL 37344 has an anti-oxidant protective effect in rats with RE. PMID: 25804391
10. The upregulation of beta3-adrenoreceptor (AR) and endothelial nitric oxide synthase proteins following heart failure were also attenuated by matrine. PMID: 25322941
11. ADRB3 partially mediates the development of COMT-dependent pain by increasing production of nitric oxide and proinflammatory cytokines. PMID: 24727346
12. results demonstrate that the activation of beta3-adrenoceptors inhibits neurogenic contractions ofboth rat and human urinary bladder. PMID: 24378642
13. beta3-Adrenoreceptor stimulation with BRL-37344 was associated with an increase in LA diameter and a decrease in LA function in chronic heart failure PMID: 24055266
14. Data suggest that adrb3 is involved in regulation of pancreatic islet blood flow; hyperlipidemia (triglycerides and free fatty acids) is associated with vagus nerve-dependent increase in pancreatic/islet blood flow and up-regulation of insulin secretion. PMID: 25139049
15. Adrb-mediated vasodilatation in aorta is driven by endothelial Adrb2 and Adrb3, but also by Adrb2 present in smooth muscle cells, and is coupled to the NO/cGMP pathway PMID: 23373597
16. A set of miRNAs is differently expressed in the aorta of high salt treated rats with miR-320 increased and miR-26b and -21 decreased, through beta1 and beta3-adrenoreceptor pathways. PMID: 24161401
17. this study has demonstrated that the rats which experienced early postnatal maternal separation show enhanced PHB levels in white adipose tissue, attenuated b3-AR levels, and unchanged UCP-1 levels in brown adipose tissue. PMID: 24220331
18. The level of beta3-adrenergic receptor mRNA expression is associated with the atrial mass index in rats with chronic heart failure. PMID: 23008154
19. Following immobilization stress, T cells were more vulnerable than B cells to stress due to increased beta-, beta- and betaadrenoceptors in spleen. PMID: 22248722
20. These results suggest that beta3-adrenoceptors play crucial roles in vasodilator responses to adrenaline of retinal arterioles but have minor or no effect on noradrenaline-induced responses PMID: 21901314
21. Beta3-adrenergic receptors are present in rat sacral spinal cord, and are significantly up-regulated after partial urethral obstruction. PMID: 21661032
22. Myocardial upregulation of beta(3)-AR is associated with increased oxidative stress in chronic heart failure rats. PMID: 20654104
23. beta(3)ARs are present in both bladder smooth muscle and urothelium. PMID: 21046653
24. Circadian rhythms of myocardial beta3-AR activities are disturbed after myocardial infarction and beta3-AR activation offers anti-arrhythmic protection. PMID: 20661603
25. Exercise training normalized cardiac beta3-adrenoceptor protein expression. PMID: 21054861
26. These results suggest that beta3-AR expression in age-related heart-failure rats and left ventricular function were highly correlated. PMID: 20443655
27. Noradrenaline stimulates ATP release from DRG neurons as mediated via beta(3) adrenoceptors linked to G(s) protein involving PKA activation, to cause allodynia. PMID: 20432431
28. Chronic intermittent hypobaric hypoxia suppresses beta-adrenergic receptor action in right ventricular papillary muscle through decreasing receptor density and affinity, as well as membrane-bound G(s)alpha. PMID: 20097768
29. the sympathetic tonus generated during cold-exposure acts, in brown adipose tissue, through the beta3-adrenergic receptor and modulates insulin signal transduction, with the exception of ERK PMID: 15750837
30. Adrb3 antagonist causes antidepressant-like effects on REM sleep, possibly mediated by increased central 5-HT synthesis. PMID: 17092981
31. In this physiological model of cardiac hypertrophy, an increase of beta(3) AR density without beta(3) AR mRNA alteration was observed. PMID: 17131040
32. beta(3)-Adrenoceptor expression is increased in the failing ventricles in rats. PMID: 17440824
33. Provides functional evidence for the presence of beta(3)-adrenergic receptor in rat hearts. PMID: 17600560
34. demonstration of expression of beta(3)-AR in the enteric nervous system PMID: 17631141
35. beta3-AR are upregulated during sepsis in the human myocardium and by cytokines in murine cardiomyocytes, where they mediate an increased negative inotropic response to beta3 agonists. PMID: 17999941
36. Here we describe an atypical state of the beta(3)-adrenoceptor that exists endogenously in adipose tissue PMID: 18031735
37. In ileum, adrenergic inhibition of contractility was dependent on muscular beta3-adrenergic receptor(AR) pathways. Posttransplant hypersensitivity was due to upregulated neuronal beta1- and beta2-AR mechanisms inactive before transplantation. PMID: 18154937
38. colitis was associated with a decreased expression of beta(3)-adrenoceptor mRNA in the mucosal/submucosal layer of distal colon; adrenoceptor immunoreactivity was decreased in inflamed tissues compared to controls, particularly in the myenteric plexus PMID: 18492028
39. Mycocardial Adrb3 is increased in type diabetes. PMID: 18583384
40. Metoprolol increases the expression of beta(3)-adrenoceptors in the diabetic heart and repressed FOXO-3 expression. PMID: 18703049
41. Stimulation of beta3-adrenoceptors relaxes rat urinary bladder smooth muscle via activation of the large-conductance Ca2+-activated K+ channels. PMID: 18799656
42. Results show that expression of different adrenoceptor subtypes in the heart is regulated differently by various stressors, and suggest a protective role of beta(2)-, beta(3)-AR, and alpha(1B)-AR in the process of heart adaptation to chronic stress. PMID: 19120133
43. These results suggest that acute cold exposure resulted in down-regulation of CIDEA in interscapular brown adipose tissue by sympathetically activated beta(3)-adrenoreceptor-mediated mechanisms in rats. PMID: 19577538
44. the effect of beta(3)-adrenoceptor (AR) in regulating resting intracellular Ca(2+) concentration of the ventricular myocytes and the signaling pathway in rats with experimental heart failure PMID: 19726315
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 1 family, Adrenergic receptor subfamily, ADRB3 sub-subfamily
組織特異性：

White and brown adipose tissues, and digestive tract.
數(shù)據(jù)庫鏈接：

KEGG: rno:25645

STRING: 10116.ENSRNOP00000016907

UniGene: Rn.10100