Recombinant Mouse Trimeric intracellular cation channel type B (Tmem38b)

in vitro E.coli expression system

中文名稱：

小鼠Tmem38b重組蛋白
貨號：

CSB-CF872037MO
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

Tmem38b
Uniprot No.：

Q9DAV9
別名：

Tmem38b; D4Ertd89e; Mg33b; Trimeric intracellular cation channel type B; TRIC-B; TRICB; Mitsugumin-33B; Transmembrane protein 38B
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-292
氨基酸序列

MEYPWDDLTLAFSRTSMFPFFDIAHYLVSVMALKQRPGAVAAAWNNPLASWLSAMLHCFG GGILSCMLLAESPLKFLTNHTNILLASSIWYIVFFCPRDLVSQGYSYQPIQFLAAGMKEV TRTWKIVGGVSDANSYYRNAWIVMIVVGWARGAGGAVVTACEQLLKGDWKPEGDEWLKMS FPCKITLLGSIMFTFQHTRHLAISKHDLMFLYTIFLVTIKVTMMMTKDTAVTLTPFEDTL TRMLFGRRQQQQFSSSEKKTEVKPSSNGSASSASKRGAEPSGGAKRHAKKED
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.
基因功能參考文獻：
1. TRIC-B function is essential to support the production and release of large amounts of collagen by osteoblasts, which is necessary for bone mineralization PMID: 27188440
2. This mini-review focuses on the essential role of TRIC-B channels in bone ossification. PMID: 27803445
3. Study found that a simplified, linear, six-state gating model best encompasses the complexity of the subconductance gating behavior of TRIC-B channels PMID: 26200862
4. Rapid transitions between TRIC-B sub-conductance states prevented development of reliable gating models. PMID: 23467973
5. TRIC-A and TRIC-B seem to have differential functions in Ca(2+) signaling in excitable and nonexcitable cells. PMID: 24526676
6. TRIC channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores PMID: 17611541
7. TRIC-B-knockout neonates were cyanotic owing to respiratory failure and died shortly after birth. In mutant neonates, the deflated lungs exhibited severe histological defects, and alveolar type II epithelial cells displayed ultrastructural abnormalities. PMID: 19515693
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亞細胞定位：

Endoplasmic reticulum membrane; Multi-pass membrane protein.
蛋白家族：

TMEM38 family
組織特異性：

Widely expressed.
數據庫鏈接：

KEGG: mmu:52076

STRING: 10090.ENSMUSP00000030127

UniGene: Mm.27184