Recombinant Mouse Interleukin-13 receptor subunit alpha-2 (Il13ra2)

in vitro E.coli expression system

中文名稱：

小鼠Il13ra2重組蛋白
貨號(hào)：

CSB-CF011592MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

基因名：

Il13ra2
Uniprot No.：

O88786
別名：

Il13ra2; Interleukin-13 receptor subunit alpha-2; IL-13 receptor subunit alpha-2; IL-13R subunit alpha-2; IL-13R-alpha-2; IL-13RA2; CD antigen CD213a2
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達(dá)區(qū)域：

22-383
氨基酸序列

LEIKVNPPQDFEILDPGLLGYLYLQWKPPVVIEKFKGCTLEYELKYRNVDSDSWKTIITRNLIYKDGFDLNKGIEGKIRTHLSEHCTNGSEVQSPWIEASYGISDEGSLETKIQDMKCIYYNWQYLVCSWKPGKTVYSDTNYTMFFWYEGLDHALQCADYLQHDEKNVGCKLSNLDSSDYKDFFICVNGSSKLEPIRSSYTVFQLQNIVKPLPPEFLHISVENSIDIRMKWSTPGGPIPPRCYTYEIVIREDDISWESATDKNDMKLKRRANESEDLCFFVRCKVNIYCADDGIWSEWSEEECWEGYTGPDSKIIFIVPVCLFFIFLLLLLCLIVEKEEPEPTLSLHVDLNKEVCAYEDTLC
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Binds as a monomer with high affinity to interleukin-13 (IL13).
基因功能參考文獻(xiàn)：
1. Upon lipopolysaccharide stimulation, macrophage Raw 264.7 cells showed elevated IL-13R-alpha-2 expression via immunofluorescence staining and increased MRI probe binding via built-in TAMRA fluorescence imaging. for the first time, IL-13R-alpha-2 was investigated as a unique biomarker in the context of osteomyelitis. PMID: 28061526
2. Study presents evidence that PNR could promote ERalpha-negative breast cancer metastasis through activation of IL-13Ralpha2-mediated signaling pathway. PMID: 24747967
3. overexpression of IL-13Ra2 inhibits the IL-13 induction of fibrotic markers in vitro and inhibits bleomycin-induced pulmonary fibrosis. PMID: 25659898
4. data collectively support a distinct role for membrane IL-13Ralpha2 in the lung and suggest that memIL-13Ralpha2 might contribute to allergic inflammation PMID: 23763980
5. When combined with IL-13Ralpha2 DNA cancer vaccine, Pseudomonas aeruginosa exotoxin A mediates synergistic antitumor effects on tumor growth and metastasis in established murine breast carcinoma and sarcoma tumor models. PMID: 22013118
6. IL-13Ralpha2 serves a protective role in the pathogenesis of allergic inflammation and loss of skin barrier function in a mouse model of atopic dermatitis. PMID: 20971924
7. studies illustrate the central role played by the IL-13Ralpha2 in the down-regulation of a chronic and pathogenic Th2-mediated immune response PMID: 12642601
8. IL-13 receptor alpha2 PMID: 14652008
9. by suppressing IFN-gamma and up-regulating the decoy IL-13 receptor, P-selectin dramatically inhibits the pathologic tissue remodeling that results from chronic type 2 cytokine-mediated hepatic inflammation PMID: 14999686
10. IL-13Ralpha2 is a selective and powerful inhibitor of IL-13-induced inflammatory, remodeling, and physiologic responses in the murine lung. PMID: 18097054
11. Restoration of tumor immunosurveillance via targeting of interleukin-13 receptor-alpha 2. PMID: 18451175
12. study concludes that matrix metalloproteinase-8 cleaves IL-13R alpha 2 in vitro and contributes to the solubilization of IL-13R alpha 2 in vivo PMID: 18694590
13. Human and murine neuroendocrine pheochromocytoma overexpress the IL-13Ralpha2 chain, and an IL-13PE-based receptor-directed anticancer approach may prove useful in treatment for metastatic pheochromocytoma patients. PMID: 19491224
14. IL-13Ralpha2 plays an important role in nematode infection by limiting the availability of IL-13 during infection, thereby regulating both the immune and biological effects of IL-13. PMID: 19587021
15. IL-13Ralpha2 in macrophages may be a critical contributor to pathogenesis of schistosomiasis. PMID: 19719966
16. Humans only express the membrane bound form of the IL-13 receptor alpha 2 PMID: 18307523
17. The IL-13 receptor alpha 2 can be used to inhibit type-2 cytokine-mediated inflammation in the lung. PMID: 9916716
18. A soluble form of the IL-13 receptor alpha 2 inhibited IL-13 activity and the progression of liver fibrosis in schistosomiasis. PMID: 10491413
19. The IL-13 receptor alpha 2 suppresses granuloma formation, liver fibrosis, and portal hypertension in schistosomiasis and acts as a life-sustaining off signal for chronic and pernicious inflammation. PMID: 14699044
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亞細(xì)胞定位：

[Isoform 1]: Membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
蛋白家族：

Type I cytokine receptor family, Type 5 subfamily
數(shù)據(jù)庫鏈接：

KEGG: mmu:16165

STRING: 10090.ENSMUSP00000033646

UniGene: Mm.368330