Recombinant Mouse Bestrophin-2 (Best2)

in vitro E.coli expression system

中文名稱：

Recombinant Mouse Bestrophin-2(Best2)
貨號：

CSB-CF805252MO
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

Best2
Uniprot No.：

Q8BGM5
別名：

Best2; Vmd2l1; Bestrophin-2; Vitelliform macular dystrophy 2-like protein 1
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-508
氨基酸序列

MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEEQKR YFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAGTVHGRDDR GRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNK YWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVV TIAVYSYFLACLIGRQFLDPAQGYKDHTLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGE DDDDFETNFLIDRNFQVSMLAVDEMYDDLAMLEKDLYWDAAEARAPYTAATAFLLQQPSF QGSTFDIALAKEDMQFQRLDGVDGPLGEVHGDFLQRLLPAGAGSVGPLGRRLSLLRRKNS CVSEASTAASCGCAGAADGGGVECGCGDPLLDPSLREPELEPPACPEPPAPIPGPTPEPF TTVSIPGPRAPAPPWLPSPIGEEEESPA
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
基因功能參考文獻：
1. Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon PMID: 20407206
2. Best2 plays a role in the generation of IOP by regulating formation of aqueous humor, and inhibition of Best2 function represents an attractive new avenue for regulating IOP in individuals with glaucoma. PMID: 18385076
3. Determined HCO3(-)/Cl(-) transport via Best2 and the effect of disease causing mutations. PMID: 18400985
4. suggest a role of bestrophin 1 and 2 for Ca(2+) dependent Cl(-) secretion in mouse airways PMID: 18652850
5. Asp-rich domain has two defined binding sites and D301A and D304A mutations may impact the binding of the metal ions PMID: 19262692
6. Results suggest that bestrophin 2 plays a critical role during differentiation and growth of axons and cilia. PMID: 19480000
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

Bestrophin family
組織特異性：

Mainly confined to the retinal pigment epithelium and colon.
數據庫鏈接：

KEGG: mmu:212989

STRING: 10090.ENSMUSP00000053408

UniGene: Mm.215154