Recombinant Mouse Aquaporin-5 (Aqp5)

in vitro E.coli expression system

中文名稱：

Recombinant Mouse Aquaporin-5(Aqp5)
貨號(hào)：

CSB-CF896235MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

基因名：

Aqp5
Uniprot No.：

Q9WTY4
別名：

Aqp5; Aquaporin-5; AQP-5
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-265
氨基酸序列

MKKEVCSVAFFKAVFAEFLATLIFVFFGLGSALKWPSALPTILQISIAFGLAIGTLAQALGPVSGGHINPAITLALLIGNQISLLRAIFYVAAQLVGAIAGAGILYWLAPGNARGNLAVNALSNNTTPGKAVVVELILTFQLALCIFSSTDSRRTSPVGSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSPSHWVFWVGPIVGAVLAAILYFYLLFPSSLSLHDRVAVVKGTYEPEEDWEDHREERKKTIELTAH
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Forms a water-specific channel. Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands.
基因功能參考文獻(xiàn)：
1. Results indicate that autophagy plays a crucial role in aquaporin 5 (AQP5) degradation in diabetic submandibular gland (SMG). PMID: 29951954
2. A daily rhythm was detected in the expression profiles of Aqp5 in submandibular glands in vivo. PMID: 28484984
3. AQP5 immunoreactivity was found in the isthmic muscle and lamina propria beneath the epithelia. In cycling females, oviduct aqp5 mRNA levels were the highest at oestrus and the lowest at dioestrus. AQP5 immunoreactivity in non-ciliated cells was notable in the infundibulum, where AQP5 was relatively high at oestrus but low at dioestrus & pro-oestrus, indicating synchrony between aqp5 gene activation and the ovarian cycle. PMID: 26272113
4. RUNX1 is essential for the development of the granular convoluted tubules in the submandibular glands; RUNX1 could also be involved in the membrane trafficking of the AQP5 protein of the acinar cells in the SMG in order to allow for the proper secretion of saliva PMID: 28877240
5. The AQP5 genotype may influence survival following lipopolysaccharides by altering neutrophil cell migration. PMID: 27871297
6. Adjusting AQP5 protein levels could be considered a therapeutic strategy for the treatment of acute pulmonary edema induced by H2S and other hazardous gases PMID: 28088675
7. GTP-dependent AQP5 expression could act as osmosensor PMID: 24662389
8. AQP5 promoter methylation is not a universal mechanism for AQP5 regulation. PMID: 25767807
9. The activation of P2X7 receptor was connected with an increase of aquaporin-5, whereas the inhibition of the receptor with oxidized ATP resulted in down regulation of aquaporin-5. PMID: 24941004
10. Lung AQP1 and AQP5 expression were significantly decreased in mice with acute lung injury together with increased inflammatory reaction and apoptosis of alveolar epithelial and vascular endothelial cells PMID: 24879973
11. The co-regulation of pendrin and AQP5 membrane expression under chronic K(+)-deficiency indicates that these two molecules could cooperate as an osmosensor to rapidly detect and respond to alterations in luminal fluid osmolality. PMID: 24429825
12. propose a new function of AQP5 as an inflammatory signal potentiator, which may be mediated by increased activation of ERK and NF-kappaB PMID: 24747567
13. AQP5 plays an important role in high altitude pulmonary edema formation induced by high altitude simulation. PMID: 24274330
14. Administration of cevimeline maintains the proper localization of AQP-5 in the acinar cells of the salivary glands of mice with Sjogren's syndrome. PMID: 23925155
15. this is the first report providing evidence that AQP5 facilitates maintenance of lens transparency and homeostasis by regulating osmotic swelling caused by glucose transporters and cotransporters under hyperglycemic stressful conditions. PMID: 24148248
16. The regulated AQP5 translocation may contribute to sweat secretion by increasing the water permeability of apical plasma membranes of sweat glands. PMID: 23473857
17. Hypoxia decreases aquaporin 5 (AQP5) expression through both hypoxia inducible factor-1alpha and proteasome-mediated pathways. PMID: 23469202
18. upregulated Aqp5 may contribute to polyuria, possibly by impairing Aqp2 membrane localization, in Dot1l(AC) mice and in patients with diabetic nephropathy. PMID: 23326416
19. AQP5 is a significant component of lens fiber cell membranes, representing the second most abundant water channel in these cells. PMID: 23313152
20. AQP5-mediated high plasma membrane water permeability enhances the apoptosis rate of differentiating bone marrow-derived mesenchymal stem cells. PMID: 22420587
21. Phosphokinase A induces AQP5 internalization in the corneal epithelial cells. PMID: 22550388
22. Aquaporin-5 was present at the apical face of the olfactory epithelium, completing a water transport pathway to the surface of the epithelium. PMID: 21745799
23. These data provide more evidence that AQP5 plays important roles in the metastasis potential of lung cancer PMID: 21193966
24. results indicate that AQP1 and AQP5 are closely related to pulmonary edema but not to eosinophil infiltration or mucus secretion during asthma. PMID: 22226856
25. AQP5 plays a role during embryonic salivary gland development. PMID: 21818558
26. AQP5 is phosphorylated at its Thr259 by PKA through cAMP, but not Ca(2+), signaling pathways. This phosphorylation does not contribute to AQP5 trafficking in the salivary gland cells. PMID: 21633078
27. The results implicate involvement of aquaporin 5 in the development of airway inflammation and mucous hyperproduction during chronic asthma. PMID: 20550619
28. results also showed that AQP5 expression increases MUC5AC and MUC5B mucin production PMID: 21455588
29. AQP5 expression first occurs in a scattered pattern in the late canalicular stage and becomes more prominent and organized in the terminal tubuli/pro-acinar cells towards birth PMID: 21203896
30. These results suggest that LPS-induced potential down-regulation of expression of AQP5 mRNA in the parotid gland is mediated via a complex(es) of these two classes of transcription factors, NF-kappaB and p-c-Jun/c-Fos. PMID: 20522648
31. Decreased expression of AQP-1 and AQP-5 in aged mice is sufficient to cause a significant decrease in alveolar water transport. PMID: 19215235
32. We conclude that the presence of AQP5 in plasma membranes of sweat glands is essential for secretion, providing potential insight into mechanisms underlying mammalian thermoregulation, tactile sensitivity, and the pathophysiology of hyperhidrosis PMID: 11773623
33. These data indicate that skeletal muscle cells express AQP5 protein and its expression is regulated by differentiation and hypertonic stress. PMID: 11989981
34. these results indicate the expression of AQP5 in sweat gland secretory epithelium, but provide direct evidence against its physiological involvement in sweat fluid secretion in mice PMID: 12042359
35. Dynamically expressed in developing mouse inner ear. Adult Aqp5 knockout mice show normal hearing and normal inner ear structural development. Redundant or alternative mechanisms likely regulate water homeostasis in developing and mature inner ear. PMID: 12943377
36. cAMP and beta-adrenergic agonists produce distinct short and long term effects on AQP5 distribution and abundance that may contribute to regulation of lung water homeostasis. PMID: 15536076
37. Aquaporin-1, -3, and -5 dependent water-transporting properties of cornea and conjunctiva. PMID: 15557451
38. atRA increases AQP5 expression through transactivation of Sp1, leading to an increase in plasma membrane water permeability. PMID: 17097063
39. There is a gender-influenced molecular mechanism involving AQP5 that allows transcellular and paracellular routes of water transport to act in conjunction. PMID: 17360692
40. AQP5 may be involved in topiramate-induced hypohidrosis. PMID: 17521680
41. Submandibular glands from 24-week-old NOD mice displayed inflammatory infiltrates, increased AQP5 protein expression, and impaired AQP5 distribution. PMID: 17665453
42. This is the first evidence demonstrating an association between AQP5 and a signaling pathway, namely the Ras signal transduction pathway, which may be the basis of the oncogenic properties seen in AQP-overexpressing cells. PMID: 18155156
43. AQP5 expression was needed for shear-induced barrier enhancement PMID: 18305162
顯示更多

收起更多
亞細(xì)胞定位：

Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein.
蛋白家族：

MIP/aquaporin (TC 1.A.8) family
組織特異性：

Detected at the luminal membrane of secretory epithelial cells in hindpaw sweat glands. Detected in acinar cells in salivary glands, in duct cells in lacrimal glands and in lung (at protein level). Detected in lung, parotid, submandibular, sublingual, and
數(shù)據(jù)庫鏈接：

KEGG: mmu:11830

STRING: 10090.ENSMUSP00000085530

UniGene: Mm.45580