Recombinant Mouse Aquaporin-11 (Aqp11)

in vitro E.coli expression system

中文名稱：

Recombinant Mouse Aquaporin-11(Aqp11)
貨號：

CSB-CF804799MO
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

Aqp11
Uniprot No.：

Q8BHH1
別名：

Aqp11; Aquaporin-11; AQP-11
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達區域：

1-271
氨基酸序列

MSALLGLRPEVQDTCISLGLMLLFVLFVGLARVIARQQLHRPVVHAFVLEFLATFQLCCCTHELQVLSEQDSAHPTWTLTLIYFFSLVHGLTLVGTASNPCGVMMQMILGGMSPEMGAVRLLAQLVSALCSRYCISALWSLSLTKYHYDERILACRNPIHTDMSKAIIIEAICSFIFHSALLHFQEVRTKLRIHLLAALITFLAYAGGSLTGALFNPALALSLHFPCFDELFYKFFVVYWLAPSVGVLMMILMFSFFLPWLHNNQMTNKKE
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain. In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway. Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER. Plays a role in the proximal tubule function by regulating its endosomal acidification. May play a role in postnatal kidney development.
基因功能參考文獻：
1. We conclude that Aqp11(-/-) mice develop cyst-like dilated proximal tubules without documented cysts at time of death. PMID: 27582095
2. The results suggest the involvement of autophagy in the development and maintenance of kidney cysts in AQP11(-/-) mice. PMID: 27916883
3. AQP11 was expressed mainly in the pia matter with limited expression in the capillary at early postnatal stages at P1~P14. PMID: 27258268
4. impaired glycosylation processing and aberrant membrane trafficking of PC-1 in AQP11(-/-) mice could be a key mechanism of cystogenesis in AQP11(-/-) mice PMID: 24854278
5. Our results indicate an important role for AQP11 to prevent glucose-induced oxidative stress in proximal tubules. PMID: 23486012
6. deletion of AQP11 results in disrupted rough endoplasmic reticulum homeostasis and increased sensitivity to rough endoplasmic reticulum injury upon metabolic challenge with amino acid PMID: 23275615
7. mouse aquaporin 11 could be involved in slow but constant water movement across the membrane PMID: 21251984
8. important role during salivary gland development PMID: 20156259
9. Immunohistochemistry of mouse testis across development pinpointed first appearance of AQP11 coinciding with late stage elongated spermatids. cDNA analysis yielded conformation of sequence. Western blotting revealed additional forms. PMID: 19812234
10. AQP11 is essential for the proximal tubular function PMID: 16107722
11. These results provide new insights into the physiological roles of AQP11. PMID: 18606867
12. mutation causing single amino acid substitution in aquaporin 11 causes renal failure in sudden juvenile death syndrome mutant mice PMID: 18701606
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亞細胞定位：

Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm. Cytoplasm, perinuclear region.
蛋白家族：

MIP/aquaporin (TC 1.A.8) family, AQP11/AQP12 subfamily
組織特異性：

Highly expressed in the S1 proximal tubule segment,. Expressed in the testis, kidney, and liver. Weakly expressed in the heart, brain, and muscle. Highly expressed in the testis. Expressed in the proximal tubule of the cortex of 8-day-old mouse kidney. Ex
數據庫鏈接：

KEGG: mmu:66333

STRING: 10090.ENSMUSP00000082054

UniGene: Mm.29756