Recombinant Mouse Amyloid-like protein 2 (Aplp2)

in vitro E.coli expression system

中文名稱：

Recombinant Mouse Amyloid-like protein 2(Aplp2)
貨號：

CSB-CF001912MO
說明書：

MSDS Datasheet
規格：
來源：

in vitro E.coli expression system
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

基因名：

Aplp2
Uniprot No.：

Q06335
別名：

Aplp2; APPL2; Amyloid beta precursor like protein 2; Amyloid beta; A4 precursor-like protein 2; Amyloid protein homolog; Amyloid-like protein 2; APLP-2; CDEI box-binding protein; CDEBP; Sperm membrane protein YWK-II
種屬：

Mus musculus (Mouse)
蛋白長度：

Full Length of Mature Protein
表達區域：

32-707
氨基酸序列

GYIEALAANAGTGFAVAEPQIAMFCGKLNMHVNIQTGKWEPDPTGTKSCLGTKEEVLQYCQEIYPELQITNVMEANQPVNIDSWCRRDKRQCKSHIVIPFKCLVGEFVSDVLLVPDNCQFFHQERMEVCEKHQRWHTLVKEACLTEGLTLYSYGMLLPCGVDQFHGTEYVCCPQTKTVDSDSTMSKEEEEEEEDEEDEEEDYDLDKSEFPTEADLEDFTEAAADEEEEDEEEGEEVVEDRDYYYDPFKGDDYNEENPTEPSSEGTISDKEIVHDVKVPPTPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKKEWEEAELQAKNLPKTERQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRRRIALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVLAVDPEKAAQMKSQVMTHLHVIEERRNQSLSLLYKVPYVAQEIQEEIDELLQEQRADMDQFTSSISENPVDVRVSSEESEEIPPFHPLHPFPSLSENEDTQPELYHPMKKGSGMAEQDGGLIGAEEKVINSKNKMDENMVIDETLDVKEMIFNAERVGGLEEEPESVGPLREDFSLSSNALIGLLVIAVAIATVIVISLVMLRKRQYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLEQMQI
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal 10xHis-tagged
產品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts.
基因功能參考文獻：
1. APLP2 couples retina development and synaptic genes and present the first evidence that APLP2 expression may be linked to synaptic disease. PMID: 27267879
2. These data support the notion that APP and APLP2 facilitate transmitter release, likely through the interaction with the neurotransmitter release machinery. PMID: 26551565
3. This paper demonstrates an important role for APLP2 in refractive development in mice and humans, suggesting a high level of evolutionary conservation of the signaling pathways underlying refractive eye development. PMID: 26313004
4. Study provides compelling evidence for an essential role of both APP and APLP2 for neuronal and synaptic morphology as well as hippocampal function and suggest an acute and specific function of endogenous APPsalpha to facilitate synaptic plasticity PMID: 25432317
5. The study investigates the subcellular distribution patterns of the metal ions Cu, Zn, Fe, and Ca in individual neurons derived from APP and APLP2 knockout mice brains to further define their role in metal homeostasis. PMID: 25098278
6. This study further highlights the distinct and essential role of APLP2 at NMJ synapses that cannot be compensated by APP. PMID: 24998676
7. Amyloid precursor protein (APP)/APP-like protein 2 (APLP2) expression is required to initiate endosome-nucleus-autophagosome PMID: 24898256
8. The study investigated copper, iron, zinc and manganese levels in APP and APLP-2 single knockout mice as well as homozygous:hemizygous knockout mice at 3, 12 and 18 plus months of age. PMID: 24448592
9. Data reveal that APLP2 is specifically required for proper cell cycle exit of neuronal progenitors, and thus has a distinct role in priming cortical progenitors for neuronal differentiation. PMID: 23345401
10. APLP2 and the intracellular domain of APP are not essential for coherent activity patterns in the hippocampus, but have subtle effects on synaptic plasticity and fine-tuning of network oscillations. PMID: 23585881
11. Gain and loss of function experiments demonstrate that miR-153 suppresses expression of amyloid precursor protein (APP) and APLP2. PMID: 22510281
12. These studies highlight the so far underestimated functional importance of APLP2 for CNS physiology. PMID: 21931985
13. [review] Studies of protein expression in knock-out mice demonstrate that APP and APLP2 do indeed play an important role in synaptic plasticity. PMID: 22006270
14. APLP2 appears not to be essential for maintenance of dendritic structure, spine density, or synaptic function PMID: 22353605
15. proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and gamma-secretase PMID: 21695060
16. Collectively, these data show that APLP2 and APP are synergistically required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. PMID: 21522131
17. Data show there were no differences in expression were detectable between wt and floxed alleles. PMID: 20140888
18. role in inducing neuronal death is mediated by impairment of the neuroprotective calcium/calmodulin protein kinase IV-dependent signaling pathway PMID: 11877414
19. The levels of APLP2 proteolytic products were decreased in BACE KO mice, but increased in BACE transgenic mice. Overexpression of BACE in cultured cells led to increased APLP2 processing. PMID: 15080893
20. The APLP2 gene has both a GAGA sequence and a CAGA box immediately upstream of a position corresponding to the APP gene CAGA box. PMID: 15208260
21. These findings provide evidence for the role of amyloid-beta precursor protein in copper homeostasis and support the hypothesis that amyloid-beta precursor protein and amyloid precursor-like protein-2 are copper-binding proteins with interchangeable roles PMID: 15447675
22. Data describe a relationship between heparan sulfate and copper binding of amyloid precursor protein (APP) and amyloid precursor-like protein 2 (APLP2) in the modulation of nitroxyl anion-catalyzed heparan sulfate degradation in glypican-1. PMID: 15677459
23. Mice deficient in APlP2 exhibit aberrant apposition of presynaptic marker proteins with postsynaptic acetylcholine receptors and excessive nerve terminal sprouting. APLP2 is a key regulators of structure & function of developing neuromuscular synapses. PMID: 15689559
24. Occurrence of the YWK-II protein in the plasma membranes of mouse gametes suggests its involvement in sperm-egg interaction. PMID: 16177981
25. findings demonstrate that the APLP2-intracellular C-terminal domains interact with CP2 transcription factor in the nucleus and induce the expression of glycogen synthase kinase 3beta PMID: 16645641
26. specific domains of the extracellular region of YWK-II protein may be involved in sperm-egg interaction PMID: 16720320
27. The results demonstrated that cell viability and neurite outgrowth of N2a cells undergoing knockdown of Aplp1 were significantly reduced, compared with N2a cells undergoing knockdown of either App or Aplp2. PMID: 16889988
28. APLP2/MHC association is influenced by multiple domains of the MHC class I heavy chain and by beta(2)m's effects on the conformation of the heavy chain. PMID: 18452037
29. APP and amyloid precursor-like protein 2 (APLP2) have a significant role in the development of synaptic function by the regulation of glutamatergic neurotransmission PMID: 18535156
30. Amyloid precursor like protein-2 and amyloid beta protein precursor share overlapping anticoagulant functions with regard to regulating thrombosis after cerebral vascular injury. PMID: 19403832
31. APP and amyloid precursor-like protein 2 are expressed by stromal cells of thymus and lymph nodes, but not by lymphocytes. PMID: 19710207
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亞細胞定位：

Cell membrane; Single-pass type I membrane protein. Nucleus.
蛋白家族：

APP family
數據庫鏈接：

KEGG: mmu:11804

STRING: 10090.ENSMUSP00000072428

UniGene: Mm.19133